Fermented Brown Rice Extract Causes Apoptotic Death of Human Acute Lymphoblastic Leukemia Cells via Death Receptor Pathway

Mixture of brown rice and rice bran fermented with Aspergillus oryzae , designated as FBRA, has been reported to reveal anti-carcinogenic and anti-inflammatory effects in rodents. Then, to test its potential anti-cancer activity, the aqueous extract was prepared from FBRA powder, and the effect of t...

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Bibliographic Details
Published in:	Applied biochemistry and biotechnology Vol. 178; no. 8; pp. 1599 - 1611
Main Authors:	Horie, Yukiko, Nemoto, Hideyuki, Itoh, Mari, Kosaka, Hiroaki, Morita, Kyoji
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-04-2016 Springer Nature B.V
Subjects:	Apoptosis Apoptosis - drug effects Aspergillus oryzae Biochemistry Biotechnology Caspase 8 - biosynthesis Caspase Inhibitors - administration & dosage Caspase Inhibitors - chemistry Cell Line, Tumor Chemistry Chemistry and Materials Science Deoxyribonucleic acid DNA Fermentation Functional foods & nutraceuticals Gene Expression Regulation, Leukemic - drug effects Humans Leukemia Mortality Oryza - chemistry Plant Extracts - administration & dosage Plant Extracts - chemistry Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Receptors, Death Domain - genetics Rice Rice bran Jurkat cells Apoptotic cell death Fermented brown rice Death receptors Non-mitochondrial pathway Rice bran
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