Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ). The genes that govern this process, however, have remained elusive. To this end, we combined distinct mouse strains with transcriptomics to directly identify disease-relevant genes. We show that AD model mice (APP -Tg)...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 7; pp. 2638 - 2643
Main Authors:	Morihara, Takashi, Hayashi, Noriyuki, Yokokoji, Mikiko, Akatsu, Hiroyasu, Silverman, Michael A., Kimura, Nobuyuki, Sato, Masahiro, Saito, Yuhki, Suzuki, Toshiharu, Yanagida, Kanta, Kodama, Takashi S., Tanaka, Toshihisa, Okochi, Masayasu, Tagami, Shinji, Kazui, Hiroaki, Kudo, Takashi, Hashimoto, Ryota, Itoh, Naohiro, Nishitomi, Kouhei, Yamaguchi-Kabata, Yumi, Tsunoda, Tatsuhiko, Takamura, Hironori, Katayama, Taiichi, Kimura, Ryo, Kamino, Kouzin, Hashizume, Yoshio, Takeda, Masatoshi
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 18-02-2014 National Acad Sciences
Subjects:	Alleles Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimers disease Amyloid beta-Peptides - metabolism Amyloids Animals Biological Sciences Brain - metabolism Crosses, Genetic Gene Expression Profiling Genes Genomes Human genetics Humans Medical genetics Mice Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Nervous system diseases Pathology Protein Isoforms - genetics Protein Isoforms - metabolism Species Specificity Transcriptomics alternative splicing mouse-to-human translation
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