Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

• Published in: International journal of cardiology Vol. 189; pp. 105 - 107
• Main Authors: Garnier, Sophie, Hengstenberg, Christian, Lamblin, Nicolas, Dubourg, Olivier, De Groote, Pascal, Fauchier, Laurent, Trochu, Jean-Noël, Arbustini, Eloisa, Esslinger, Ulrike, Barton, Paul J, Meder, Benjamin, Katus, Hugo, Frese, Karen, Komajda, Michel, Cook, Stuart A, Isnard, Richard, Tiret, Laurence, Villard, Eric, Charron, Philippe
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 15-06-2015
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Age Distribution; Aged; Aged, 80 and over; Apoptosis Regulatory Proteins - genetics; Cardiology and cardiovascular system; Cardiomyopathy, Dilated - etiology; Cardiomyopathy, Dilated - genetics; Cardiomyopathy, Dilated - mortality; Cardiomyopathy, Dilated - therapy; Cardiovascular; Case-Control Studies; Cohort Studies; Europe; Female; France; Gene Expression Regulation; Genetic Loci; Genome-Wide Association Study; Genotype; Germany; Heart Failure, Systolic - etiology; Heart Failure, Systolic - genetics; Heart Failure, Systolic - mortality; Heart Failure, Systolic - therapy; HSP27 Heat-Shock Proteins - genetics; Human health and pathology; Humans; Incidence; Internationality; Italy; Life Sciences; Male; Middle Aged; Prognosis; Risk Assessment; Sex Distribution; Survival Analysis; Italy; France; Europe; Germany; Association studies; Ischemic heart failure; Genetics; Dilated cardiomyopathy
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2015.04.003

Heart failure (HF), a major public health burden affecting 2% of industrialized populations, is a syndrome resulting from structural or functional myocardial impairment leading to inadequate cardiac output to meet the body's metabolic demands [1]. Half of HF patients present systolic dysfunction (systolic-HF), also called reduced ejection fraction (HF-REF), a disease related to various causes including idiopathic Dilated Cardiomyopathy (DCM) and Coronary Artery Diseases (CAD) (ischemic-HF). HF is usually a multifactorial disease but the genetic variants contributing to its susceptibility or its severity may be different according to its underlying causes [2] and their identification is only beginning.[...]