High prevalence of polycystic ovary syndrome in women with mild hirsutism and no other significant clinical symptoms
Objective To verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual irregularities, infertility, central obesity, acanthosis nigricans, rapid progression of the hirsutism, clitoromegaly) should not be further stud...
Saved in:
| Published in: | Fertility and sterility Vol. 94; no. 1; pp. 194 - 197 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New York, NY
Elsevier Inc
01-06-2010
Elsevier |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Objective To verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual irregularities, infertility, central obesity, acanthosis nigricans, rapid progression of the hirsutism, clitoromegaly) should not be further studied. Design Retrospective study in patients referred because of mild hirsutism and no other clinical signs. Setting Department of Clinical Medicine of the University of Palermo. Patient(s) One hundred fifty-two patients with mild hirsutism. Intervention(s) Measurement of serum testosterone, dehydroepiandrosterone sulfate, 17-OH-Progesterone, assessment of ovulation by measurement of progesterone in 21 to 24 days and ovarian ultrasound. Result(s) In 72 (47%) patients a diagnosis of polycyctic ovarian syndrome (PCOS) was performed. Polycyctic ovarian syndrome patients included 56 patients with the mild ovulatory form (OV-PCOS) but also 16 patients with the anovulatory form (classic PCOS). Three (2%) patients had nonclassic adrenal hyperplasia. Conclusion(s) Because of the high prevalence of PCOS and the possibility of finding nonclassic 21-hydroxylase deficiency, patients with mild hirsutism need a diagnostic evaluation that should include 17-hydroxyprogesterone measurement plus assessment of ovulation and ovarian ultrasound. |
|---|---|
| AbstractList | To verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual irregularities, infertility, central obesity, acanthosis nigricans, rapid progression of the hirsutism, clitoromegaly) should not be further studied.
Retrospective study in patients referred because of mild hirsutism and no other clinical signs.
Department of Clinical Medicine of the University of Palermo.
One hundred fifty-two patients with mild hirsutism.
Measurement of serum testosterone, dehydroepiandrosterone sulfate, 17-OH-Progesterone, assessment of ovulation by measurement of progesterone in 21 to 24 days and ovarian ultrasound.
In 72 (47%) patients a diagnosis of polycyctic ovarian syndrome (PCOS) was performed. Polycyctic ovarian syndrome patients included 56 patients with the mild ovulatory form (OV-PCOS) but also 16 patients with the anovulatory form (classic PCOS). Three (2%) patients had nonclassic adrenal hyperplasia.
Because of the high prevalence of PCOS and the possibility of finding nonclassic 21-hydroxylase deficiency, patients with mild hirsutism need a diagnostic evaluation that should include 17-hydroxyprogesterone measurement plus assessment of ovulation and ovarian ultrasound. Objective To verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual irregularities, infertility, central obesity, acanthosis nigricans, rapid progression of the hirsutism, clitoromegaly) should not be further studied. Design Retrospective study in patients referred because of mild hirsutism and no other clinical signs. Setting Department of Clinical Medicine of the University of Palermo. Patient(s) One hundred fifty-two patients with mild hirsutism. Intervention(s) Measurement of serum testosterone, dehydroepiandrosterone sulfate, 17-OH-Progesterone, assessment of ovulation by measurement of progesterone in 21 to 24 days and ovarian ultrasound. Result(s) In 72 (47%) patients a diagnosis of polycyctic ovarian syndrome (PCOS) was performed. Polycyctic ovarian syndrome patients included 56 patients with the mild ovulatory form (OV-PCOS) but also 16 patients with the anovulatory form (classic PCOS). Three (2%) patients had nonclassic adrenal hyperplasia. Conclusion(s) Because of the high prevalence of PCOS and the possibility of finding nonclassic 21-hydroxylase deficiency, patients with mild hirsutism need a diagnostic evaluation that should include 17-hydroxyprogesterone measurement plus assessment of ovulation and ovarian ultrasound. OBJECTIVETo verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual irregularities, infertility, central obesity, acanthosis nigricans, rapid progression of the hirsutism, clitoromegaly) should not be further studied.DESIGNRetrospective study in patients referred because of mild hirsutism and no other clinical signs.SETTINGDepartment of Clinical Medicine of the University of Palermo.PATIENT(S)One hundred fifty-two patients with mild hirsutism.INTERVENTION(S)Measurement of serum testosterone, dehydroepiandrosterone sulfate, 17-OH-Progesterone, assessment of ovulation by measurement of progesterone in 21 to 24 days and ovarian ultrasound.RESULT(S)In 72 (47%) patients a diagnosis of polycyctic ovarian syndrome (PCOS) was performed. Polycyctic ovarian syndrome patients included 56 patients with the mild ovulatory form (OV-PCOS) but also 16 patients with the anovulatory form (classic PCOS). Three (2%) patients had nonclassic adrenal hyperplasia.CONCLUSION(S)Because of the high prevalence of PCOS and the possibility of finding nonclassic 21-hydroxylase deficiency, patients with mild hirsutism need a diagnostic evaluation that should include 17-hydroxyprogesterone measurement plus assessment of ovulation and ovarian ultrasound. |
| Author | Di Fede, Gaetana, M.D Pepe, Ilenia, M.D Mansueto, Pasquale, M.D Carmina, Enrico, M.D Rini, Giovam Battista, M.D |
| Author_xml | – sequence: 1 fullname: Di Fede, Gaetana, M.D – sequence: 2 fullname: Mansueto, Pasquale, M.D – sequence: 3 fullname: Pepe, Ilenia, M.D – sequence: 4 fullname: Rini, Giovam Battista, M.D – sequence: 5 fullname: Carmina, Enrico, M.D |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22885424$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19338993$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkkGP1SAQgIlZ475d_QuGi_HUOkBp6cVEN7prsokH9Uwopft4tlCBPtN_L8176yaevMxw-GYYPuYKXTjvDEKYQEmA1O8O5WBCcjHlWFKAtgRaAq-foR3hvC54zdkF2gEQXgAV9BJdxXgAgJo09AW6JC1jom3ZDqU7-7DHczBHNRqnDfYDnv246jUmq7E_qrDiuLo--Mlg6_DvnHO0aY8nO_Z4b0Ncko0TVq7HzmOf9ibgaB-cHaxWLmE9WpdPY-4zzclP8SV6PqgxmlfnfI1-fP70_eauuP96--Xmw32hOYhUdL0CIUQ1VAyqhvaa1qprqrYlUHcNVJWmXUeZbntVw8AIp6bpTMdZRwclGsKu0dtT3zn4X4uJSU42ajOOyhm_RNkwBi00dZNJcSJ18DEGM8g52Cm_XRKQm3J5kE_K5aZcApVZeS59fb5k6SbTPxWeHWfgzRlQMVsYgnLaxr8cpULwilaZ-3jiTFZytCbIqO32J70NRifZe_s_07z_p8mj_Z9mNfHgl-CycklkzAXy27Yi24ZkD9kxB_YHLN-92w |
| CODEN | FESTAS |
| CitedBy_id | crossref_primary_10_1136_bcr_2018_226122 crossref_primary_10_1159_000479371 crossref_primary_10_1159_000375530 crossref_primary_10_1007_s40257_014_0078_4 crossref_primary_10_1093_humupd_dmr042 crossref_primary_10_1111_cen_14710 crossref_primary_10_1210_jc_2017_02426 crossref_primary_10_1210_jc_2018_00241 crossref_primary_10_1373_jalm_2016_020842 crossref_primary_10_1093_humupd_dmx014 crossref_primary_10_1210_clinem_dgac271 |
| Cites_doi | 10.1016/S0015-0282(98)00141-1 10.1210/jc.2004-2279 10.1210/jc.2006-0178 10.1016/j.fertnstert.2006.02.069 10.1210/jc.2007-2437 10.1093/humupd/dmg044 10.1016/S0015-0282(98)00455-5 10.1210/jc.2005-1457 10.1016/S0015-0282(16)56998-2 10.1530/eje.0.1390421 10.1210/jcem.84.6.5803 10.1016/S0015-0282(16)55152-8 10.1016/0002-9378(81)90746-8 10.1093/humrep/dei159 10.1016/j.fertnstert.2004.12.061 |
| ContentType | Journal Article |
| Copyright | American Society for Reproductive Medicine 2010 American Society for Reproductive Medicine 2015 INIST-CNRS Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: American Society for Reproductive Medicine – notice: 2010 American Society for Reproductive Medicine – notice: 2015 INIST-CNRS – notice: Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.fertnstert.2009.02.056 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1556-5653 |
| EndPage | 197 |
| ExternalDocumentID | 10_1016_j_fertnstert_2009_02_056 19338993 22885424 S0015028209004750 1_s2_0_S0015028209004750 |
| Genre | Journal Article Comparative Study |
| GroupedDBID | --- --K -~X .1- .55 .FO .GJ 0R~ 0SF 1B1 1P~ 1~5 29H 34R 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 85S AACTN AAEDT AAEDW AALRI AAQFI AAQXK AAXUO ABCQX ABFRF ABJNI ABLJU ABMAC ACGFO ACIUM ADBBV ADMUD ADPAM ADVLN AEFWE AENEX AEVXI AFCTW AFFNX AFJKZ AFRHN AFTJW AI. AITUG AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BELOY C5W CS3 DU5 EBS EFJIC EJD F5P FDB FEDTE FGOYB GBLVA HVGLF HZ~ IHE J1W J5H K-O KOM L7B M41 MO0 N9A NQ- O9- OK1 OQ. P2P PH~ R2- RIG ROL RPZ SDP SEL SES SEW SSZ UNMZH UV1 VH1 W2D X7M XH2 XJT XPP YOC YZZ Z5R ZGI ZXP ~S- AAIAV AGZHU AHPSJ ALXNB ZA5 08R AAPBV AAUGY ABPTK IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c508t-bda08884f430472dc26ab7499106b7044c2bb23c9da60f3152e7beb53b2fa8713 |
| ISSN | 0015-0282 |
| IngestDate | Fri Aug 16 11:50:24 EDT 2024 Thu Nov 21 21:17:42 EST 2024 Sat Sep 28 07:44:57 EDT 2024 Sun Oct 22 16:08:33 EDT 2023 Fri Feb 23 02:23:30 EST 2024 Tue Oct 15 14:34:14 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | hirsultism Hyperandrogenism PCOS nonclassic adrenal hyperplasia Endocrinopathy Skin disease Prevalence Adrenal glands Hyperplasia Polycystic ovary Epidemiology Cyst Female Benign neoplasm Woman Human Hair Gynecology Hirsutism Female sterility Obstetrics Female genital diseases Ovarian diseases Symptomatology Masculinization |
| Language | English |
| License | CC BY 4.0 Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c508t-bda08884f430472dc26ab7499106b7044c2bb23c9da60f3152e7beb53b2fa8713 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://www.fertstert.org/article/S0015028209004750/pdf |
| PMID | 19338993 |
| PQID | 733090767 |
| PQPubID | 23479 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_733090767 crossref_primary_10_1016_j_fertnstert_2009_02_056 pubmed_primary_19338993 pascalfrancis_primary_22885424 elsevier_sciencedirect_doi_10_1016_j_fertnstert_2009_02_056 elsevier_clinicalkeyesjournals_1_s2_0_S0015028209004750 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-06-01 |
| PublicationDateYYYYMMDD | 2010-06-01 |
| PublicationDate_xml | – month: 06 year: 2010 text: 2010-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States |
| PublicationTitle | Fertility and sterility |
| PublicationTitleAlternate | Fertil Steril |
| PublicationYear | 2010 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Balen, Laven, Tan, Dewailly (bib8) 2003; 9 Carmina, Lobo (bib16) 1999; 71 Carmina, Lobo (bib7) 1994; 62 Azziz, Waggoner, Ochoa, Knochenauer, Boots (bib15) 1998; 70 Carmina (bib6) 1998; 139 Carmina (bib13) 2006; 85 Zawdaki, Dunaif (bib14) 1992 Carmina, Stanczyk, Chang, Miles, Lobo (bib5) 1992; 58 Carmina, Orio, Palomba, Longo, Lombardi, Lobo (bib9) 2005; 84 Knochenhauer, Key, Kahsar-Miller, Waggoner, Boots, Azziz (bib17) 1998; 83 Carmina, Lobo (bib2) 1999; 84 Martyn, Chang, Ehrmann, Ibanez, Lobo, Rosenfield (bib3) 2008; 93 Carmina, Lobo (bib1) 2001 Carmina, Longo, Rini, Lobo (bib18) 2005; 90 Carmina, Rosato, Jannì, Rizzo, Longo (bib11) 2006; 91 Azziz, Carmina, Dewailly, Diamanti-Kandarakis, Escobar-Morreale, Futterweit (bib12) 2006; 91 Jonard, Robert, Dewailly (bib10) 2005; 20 Hatch, Rosenfield, Kim, Tredway (bib4) 1981; 140 Carmina (10.1016/j.fertnstert.2009.02.056_bib1) 2001 Carmina (10.1016/j.fertnstert.2009.02.056_bib6) 1998; 139 Azziz (10.1016/j.fertnstert.2009.02.056_bib12) 2006; 91 Knochenhauer (10.1016/j.fertnstert.2009.02.056_bib17) 1998; 83 Carmina (10.1016/j.fertnstert.2009.02.056_bib16) 1999; 71 Carmina (10.1016/j.fertnstert.2009.02.056_bib2) 1999; 84 Hatch (10.1016/j.fertnstert.2009.02.056_bib4) 1981; 140 Carmina (10.1016/j.fertnstert.2009.02.056_bib13) 2006; 85 Carmina (10.1016/j.fertnstert.2009.02.056_bib11) 2006; 91 Martyn (10.1016/j.fertnstert.2009.02.056_bib3) 2008; 93 Carmina (10.1016/j.fertnstert.2009.02.056_bib5) 1992; 58 Jonard (10.1016/j.fertnstert.2009.02.056_bib10) 2005; 20 Azziz (10.1016/j.fertnstert.2009.02.056_bib15) 1998; 70 Carmina (10.1016/j.fertnstert.2009.02.056_bib9) 2005; 84 Balen (10.1016/j.fertnstert.2009.02.056_bib8) 2003; 9 Carmina (10.1016/j.fertnstert.2009.02.056_bib7) 1994; 62 Zawdaki (10.1016/j.fertnstert.2009.02.056_bib14) 1992 Carmina (10.1016/j.fertnstert.2009.02.056_bib18) 2005; 90 |
| References_xml | – start-page: 991 year: 2001 end-page: 1008 ident: bib1 article-title: Hirsutism, alopecia and acne publication-title: Principles and practice of endocrinology and metabolism contributor: fullname: Lobo – volume: 84 start-page: 1897 year: 1999 end-page: 1899 ident: bib2 article-title: Polycystic ovary syndrome (PCOS), arguably the most common endocrinopathy, is associated with significant morbidity in women publication-title: J Clin Endocrinol Metab contributor: fullname: Lobo – volume: 20 start-page: 2893 year: 2005 end-page: 2898 ident: bib10 article-title: Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries publication-title: Hum Reprod contributor: fullname: Dewailly – volume: 70 start-page: 274 year: 1998 end-page: 278 ident: bib15 article-title: Idiopathic hirsutism: an uncommon cause of hirsutism in Alabama publication-title: Fertil Steril contributor: fullname: Boots – volume: 91 start-page: 2 year: 2006 end-page: 6 ident: bib11 article-title: Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism publication-title: J Clin Endocrinol Metab contributor: fullname: Longo – volume: 62 start-page: 738 year: 1994 end-page: 743 ident: bib7 article-title: Ovarian suppression reduces clinical and endocrine expression of late onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency publication-title: Fertil Steril contributor: fullname: Lobo – volume: 9 start-page: 505 year: 2003 end-page: 514 ident: bib8 article-title: Ultrasound assessment of the polycystic ovary: international consensus definitions publication-title: Hum Reprod Update contributor: fullname: Dewailly – volume: 93 start-page: 1105 year: 2008 end-page: 1120 ident: bib3 article-title: Evaluation and treatment of hirsutism in premenopausal women: an Endocrine Society Clinical Practice Guideline publication-title: J Clin Endocrinol Metab contributor: fullname: Rosenfield – volume: 140 start-page: 815 year: 1981 end-page: 830 ident: bib4 article-title: Hirsutism: implications, etiology and management publication-title: Am J Obstet Gynecol contributor: fullname: Tredway – volume: 91 start-page: 4237 year: 2006 end-page: 4245 ident: bib12 article-title: Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline publication-title: J Clin Endocrinol Metab contributor: fullname: Futterweit – volume: 90 start-page: 2545 year: 2005 end-page: 2549 ident: bib18 article-title: Phenotypic variation in hyperandrogenic women influences the finding of abnormal metabolic and cardiovascular risk parameters publication-title: J Clin Endocrinol Metab contributor: fullname: Lobo – volume: 58 start-page: 148 year: 1992 end-page: 152 ident: bib5 article-title: The ratio of androstenedione: 11β-hydroxyandrostenedione is an important marker of adrenal androgen excess in women publication-title: Fertil Steril contributor: fullname: Lobo – volume: 71 start-page: 319 year: 1999 end-page: 322 ident: bib16 article-title: Do hyperandrogenic women with normal menses have polycystic ovary syndrome? publication-title: Fertil Steril contributor: fullname: Lobo – volume: 85 start-page: 1582 year: 2006 end-page: 1585 ident: bib13 article-title: The spectrum of androgen excess disorders publication-title: Fertil Steril contributor: fullname: Carmina – start-page: 377 year: 1992 end-page: 384 ident: bib14 article-title: Diagnostic criteria for polycystic ovary syndrome: towards a rationale approach publication-title: Polycystic ovary syndrome contributor: fullname: Dunaif – volume: 84 start-page: 413 year: 2005 end-page: 419 ident: bib9 article-title: Ovarian size and blood flow in women with polycystic ovary syndrome (PCOS) and their correlations with some endocrine parameters publication-title: Fertil Steril contributor: fullname: Lobo – volume: 83 start-page: 3078 year: 1998 end-page: 3082 ident: bib17 article-title: Prevalence of the polycystic ovary syndrome in unselected black and white women of the South Eastern USA: a prospective study publication-title: J Clin Endocrinol Metab contributor: fullname: Azziz – volume: 139 start-page: 421 year: 1998 end-page: 423 ident: bib6 article-title: Prevalence of idiopathic hirsutism publication-title: Eur J Endocrinol contributor: fullname: Carmina – start-page: 991 year: 2001 ident: 10.1016/j.fertnstert.2009.02.056_bib1 article-title: Hirsutism, alopecia and acne contributor: fullname: Carmina – volume: 83 start-page: 3078 year: 1998 ident: 10.1016/j.fertnstert.2009.02.056_bib17 article-title: Prevalence of the polycystic ovary syndrome in unselected black and white women of the South Eastern USA: a prospective study publication-title: J Clin Endocrinol Metab contributor: fullname: Knochenhauer – volume: 70 start-page: 274 year: 1998 ident: 10.1016/j.fertnstert.2009.02.056_bib15 article-title: Idiopathic hirsutism: an uncommon cause of hirsutism in Alabama publication-title: Fertil Steril doi: 10.1016/S0015-0282(98)00141-1 contributor: fullname: Azziz – volume: 90 start-page: 2545 year: 2005 ident: 10.1016/j.fertnstert.2009.02.056_bib18 article-title: Phenotypic variation in hyperandrogenic women influences the finding of abnormal metabolic and cardiovascular risk parameters publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-2279 contributor: fullname: Carmina – volume: 91 start-page: 4237 year: 2006 ident: 10.1016/j.fertnstert.2009.02.056_bib12 article-title: Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-0178 contributor: fullname: Azziz – volume: 85 start-page: 1582 year: 2006 ident: 10.1016/j.fertnstert.2009.02.056_bib13 article-title: The spectrum of androgen excess disorders publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2006.02.069 contributor: fullname: Carmina – volume: 93 start-page: 1105 year: 2008 ident: 10.1016/j.fertnstert.2009.02.056_bib3 article-title: Evaluation and treatment of hirsutism in premenopausal women: an Endocrine Society Clinical Practice Guideline publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-2437 contributor: fullname: Martyn – volume: 9 start-page: 505 year: 2003 ident: 10.1016/j.fertnstert.2009.02.056_bib8 article-title: Ultrasound assessment of the polycystic ovary: international consensus definitions publication-title: Hum Reprod Update doi: 10.1093/humupd/dmg044 contributor: fullname: Balen – volume: 71 start-page: 319 year: 1999 ident: 10.1016/j.fertnstert.2009.02.056_bib16 article-title: Do hyperandrogenic women with normal menses have polycystic ovary syndrome? publication-title: Fertil Steril doi: 10.1016/S0015-0282(98)00455-5 contributor: fullname: Carmina – volume: 91 start-page: 2 year: 2006 ident: 10.1016/j.fertnstert.2009.02.056_bib11 article-title: Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-1457 contributor: fullname: Carmina – volume: 62 start-page: 738 year: 1994 ident: 10.1016/j.fertnstert.2009.02.056_bib7 article-title: Ovarian suppression reduces clinical and endocrine expression of late onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency publication-title: Fertil Steril doi: 10.1016/S0015-0282(16)56998-2 contributor: fullname: Carmina – volume: 139 start-page: 421 year: 1998 ident: 10.1016/j.fertnstert.2009.02.056_bib6 article-title: Prevalence of idiopathic hirsutism publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1390421 contributor: fullname: Carmina – volume: 84 start-page: 1897 year: 1999 ident: 10.1016/j.fertnstert.2009.02.056_bib2 article-title: Polycystic ovary syndrome (PCOS), arguably the most common endocrinopathy, is associated with significant morbidity in women publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.84.6.5803 contributor: fullname: Carmina – volume: 58 start-page: 148 year: 1992 ident: 10.1016/j.fertnstert.2009.02.056_bib5 article-title: The ratio of androstenedione: 11β-hydroxyandrostenedione is an important marker of adrenal androgen excess in women publication-title: Fertil Steril doi: 10.1016/S0015-0282(16)55152-8 contributor: fullname: Carmina – volume: 140 start-page: 815 year: 1981 ident: 10.1016/j.fertnstert.2009.02.056_bib4 article-title: Hirsutism: implications, etiology and management publication-title: Am J Obstet Gynecol doi: 10.1016/0002-9378(81)90746-8 contributor: fullname: Hatch – volume: 20 start-page: 2893 year: 2005 ident: 10.1016/j.fertnstert.2009.02.056_bib10 article-title: Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries publication-title: Hum Reprod doi: 10.1093/humrep/dei159 contributor: fullname: Jonard – start-page: 377 year: 1992 ident: 10.1016/j.fertnstert.2009.02.056_bib14 article-title: Diagnostic criteria for polycystic ovary syndrome: towards a rationale approach contributor: fullname: Zawdaki – volume: 84 start-page: 413 year: 2005 ident: 10.1016/j.fertnstert.2009.02.056_bib9 article-title: Ovarian size and blood flow in women with polycystic ovary syndrome (PCOS) and their correlations with some endocrine parameters publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2004.12.061 contributor: fullname: Carmina |
| SSID | ssj0006172 |
| Score | 2.1053157 |
| Snippet | Objective To verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual... To verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual... OBJECTIVETo verify the conclusions of the Endocrine Society Guidelines that patients with mild hirsutism and no other important clinical signs (menstrual... |
| SourceID | proquest crossref pubmed pascalfrancis elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 194 |
| SubjectTerms | 17-alpha-Hydroxyprogesterone - blood Adult Biological and medical sciences Female Female genital diseases Gynecology. Andrology. Obstetrics hirsultism Hirsutism - blood Hirsutism - diagnosis Hirsutism - epidemiology Humans Hyperandrogenism Internal Medicine Medical sciences Non tumoral diseases nonclassic adrenal hyperplasia Obstetrics and Gynecology PCOS Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - diagnosis Polycystic Ovary Syndrome - epidemiology Prevalence Puberal and climacteric disorders (male and female) Retrospective Studies Young Adult |
| Title | High prevalence of polycystic ovary syndrome in women with mild hirsutism and no other significant clinical symptoms |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0015028209004750 https://dx.doi.org/10.1016/j.fertnstert.2009.02.056 https://www.ncbi.nlm.nih.gov/pubmed/19338993 https://search.proquest.com/docview/733090767 |
| Volume | 94 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9swFBZpB2Mwxu7LLkUPezMOtuxYNnsaXdqOkTHaDsZehOzINCWxQ50M8u93ji52kyXQDfYSYllxJJ_P0qfjo-8Q8l5lEtZVUeCXXEo_ziU6msLCjzmYP0I9F4l-yLML_vVH-mkUj3o9p2bRlf1XS0MZ2Bp3zv6FtduLQgF8B5vDJ1gdPu9kdwzcwJ3_cE390GJEcz1bF2sUZPbqXxgl52QK0NmhJRiMO3Y-nU28q-lNA82zqTOq2tNbtDyM88CoIjDErd2U6_liWVu9c5frEwO1NbfXLnmUgsajljBPvRNlpH5PpQJmqsnreNAGHo9h7lwpndwJ6G2Dmz7VVpVvaqGLPs8wUnDr5PlUJ6nyTjHKdu6hfqijyK6WdXLg-3kXjOUG7hA3kqcbA7fJjrwBUDMKh_aMskd851xh3BbXgxLuS4W3Y2nlS9kgGO6Q5x4dfwn9Bk76F1qYEVoTZKi2aZRzt2S7Q9EwEYg_qh6QewzGRBySfw7PW9KARNKQBtNPG3RmQhF3t3Afk3q4kA1goDSJWfavnDSDunxMHtmlD_1oMPuE9FT1lNwf2-COZ2SJ0KUddGld0g66VEOXOujSaUU1dClClyJ0aQtdCtCjVU01dOkt6FIHXeqg-5x8PxldHp_5NimIX8BaYunnEwkTYxqXMb4wZpOCJTLnsG4PgyTnQRwXLM9ZVGQTmQRlBPRU8VzlwyhnpUx5GL0gh1VdqVeEclUmXEEFmcl4UjIZ5jDZl2WQlFFWZKpPQneDxcJovwgXFHktOqNgKtdMBGDuYdIn3FlCuC7BbKwaO0Q0Yh8w-uRD-0vLfg2rFQDYO_zv0YbZ2wYzlqbDmMV9Qh0OBMwg-FpQVqpeNYJHEbSBJ7xPXhp8dL0FoKawgnn9z716Qx50z_Nbcri8Wal35KCZrI70A_Abgdz0xg |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=High+prevalence+of+polycystic+ovary+syndrome+in+women+with+mild+hirsutism+and+no+other+significant+clinical+symptoms&rft.jtitle=Fertility+and+sterility&rft.au=Di+Fede%2C+Gaetana%2C+M.D&rft.au=Mansueto%2C+Pasquale%2C+M.D&rft.au=Pepe%2C+Ilenia%2C+M.D&rft.au=Rini%2C+Giovam+Battista%2C+M.D&rft.date=2010-06-01&rft.issn=0015-0282&rft.volume=94&rft.issue=1&rft.spage=194&rft.epage=197&rft_id=info:doi/10.1016%2Fj.fertnstert.2009.02.056&rft.externalDBID=ECK1-s2.0-S0015028209004750&rft.externalDocID=1_s2_0_S0015028209004750 |
| thumbnail_m | http://sdu.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00150282%2FS0015028210X00097%2Fcov150h.gif |