Distributed 2D temperature sensing during nanoparticles assisted laser ablation by means of high-scattering fiber sensors

• Published in: Scientific reports Vol. 10; no. 1; p. 12593
• Main Authors: Ashikbayeva, Zhannat, Aitkulov, Arman, Jelbuldina, Madina, Issatayeva, Aizhan, Beisenova, Aidana, Molardi, Carlo, Saccomandi, Paola, Blanc, Wilfried, Inglezakis, Vassilis J., Tosi, Daniele
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28-07-2020; Nature Publishing Group
• Subjects: 639/166; 639/301; 639/624/1111/1116; 639/624/1111/55; Ablation; Animals; Bioengineering; Biosensing Techniques; Fibers; Gold - chemistry; Hot Temperature; Humanities and Social Sciences; Iron oxides; Laser ablation; Laser Therapy - methods; Lasers; Life Sciences; Medical Physics; Metal Nanoparticles - chemistry; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; multidisciplinary; Nanoparticles; Physics; Science; Science (multidisciplinary); Spectrophotometry, Ultraviolet; Swine; Thermometry - methods; X-Ray Diffraction
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-69384-2

The high demand in effective and minimally invasive cancer treatments, namely thermal ablation, leads to the demand for real-time multi-dimensional thermometry to evaluate the treatment effectiveness, which can be also assisted by the use of nanoparticles. We report the results of 20-nm gold and magnetic iron oxide nanoparticles-assisted laser ablation on a porcine liver phantom. The experimental set-up consisting of high-scattering nanoparticle-doped fibers was operated by means of a scattering–level multiplexing arrangement and interrogated via optical backscattered reflectometry, together with a solid-state laser diode operating at 980 nm. The multiplexed 2-dimensional fiber arrangement based on nanoparticle-doped fibers allowed an accurate superficial thermal map detected in real-time.