Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (C...

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Published in:Frontiers in cell and developmental biology Vol. 9; p. 654210
Main Authors: Montero-Vilchez, Trinidad, Sierra-Sánchez, Álvaro, Sanchez-Diaz, Manuel, Quiñones-Vico, Maria Isabel, Sanabria-de-la-Torre, Raquel, Martinez-Lopez, Antonio, Arias-Santiago, Salvador
Format: Journal Article
Language:English
Published: Frontiers Media S.A 23-07-2021
Subjects:
advanced therapy
Cell and Developmental Biology
conditioned medium
dermatology
mesenchymal stem cells
stem cells
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Abstract The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.
AbstractList The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.
Author Montero-Vilchez, Trinidad
Sierra-Sánchez, Álvaro
Quiñones-Vico, Maria Isabel
Sanchez-Diaz, Manuel
Sanabria-de-la-Torre, Raquel
Martinez-Lopez, Antonio
Arias-Santiago, Salvador
AuthorAffiliation 1 Department of Dermatology, Virgen de las Nieves University Hospital , Granada , Spain
4 Department of Dermatology, Faculty of Medicine, University of Granada , Granada , Spain
2 Biosanitary Institute of Granada (ibs.GRANADA) , Granada , Spain
3 Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Andalusian Network of Design and Translation of Advanced Therapies , Granada , Spain
AuthorAffiliation_xml – name: 4 Department of Dermatology, Faculty of Medicine, University of Granada , Granada , Spain
– name: 2 Biosanitary Institute of Granada (ibs.GRANADA) , Granada , Spain
– name: 3 Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Andalusian Network of Design and Translation of Advanced Therapies , Granada , Spain
– name: 1 Department of Dermatology, Virgen de las Nieves University Hospital , Granada , Spain
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  surname: Montero-Vilchez
  fullname: Montero-Vilchez, Trinidad
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  surname: Sanchez-Diaz
  fullname: Sanchez-Diaz, Manuel
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  givenname: Maria Isabel
  surname: Quiñones-Vico
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  surname: Sanabria-de-la-Torre
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  surname: Martinez-Lopez
  fullname: Martinez-Lopez, Antonio
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  surname: Arias-Santiago
  fullname: Arias-Santiago, Salvador
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Edited by: Guido Moll, Charité – Universitätsmedizin Berlin, Germany
This article was submitted to Stem Cell Research, a section of the journal Frontiers in Cell and Developmental Biology
Reviewed by: Mohammad Bayat, Shahid Beheshti University of Medical Sciences, Iran; Francisco Avila, Mayo Clinic Florida, United States; Marco Patruno, University of Padua, Italy
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Snippet The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for...
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SubjectTerms advanced therapy
Cell and Developmental Biology
conditioned medium
dermatology
mesenchymal stem cells
stem cells
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Title Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review
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