Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

• Published in: Frontiers in cell and developmental biology Vol. 9; p. 654210
• Main Authors: Montero-Vilchez, Trinidad, Sierra-Sánchez, Álvaro, Sanchez-Diaz, Manuel, Quiñones-Vico, Maria Isabel, Sanabria-de-la-Torre, Raquel, Martinez-Lopez, Antonio, Arias-Santiago, Salvador
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 23-07-2021
• Subjects: advanced therapy; Cell and Developmental Biology; conditioned medium; dermatology; mesenchymal stem cells; stem cells
• ISSN: 2296-634X; 2296-634X
• DOI: 10.3389/fcell.2021.654210

The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.