Endometrial intraepithelial neoplasia

• Published in: Archives of pathology & laboratory medicine (1976) Vol. 138; no. 4; pp. 484 - 491
• Main Authors: Owings, Richard A, Quick, Charles M
• Format: Journal Article
• Language: English
• Published: United States College of American Pathologists 01-04-2014
• Subjects: Biopsy; Cancer; Carcinoma in Situ - diagnosis; Carcinoma in Situ - genetics; Carcinoma in Situ - pathology; Classification; Diagnosis, Differential; Endometrial Hyperplasia - diagnosis; Endometrial Hyperplasia - genetics; Endometrial Hyperplasia - pathology; Endometrial Neoplasms - diagnosis; Endometrial Neoplasms - genetics; Endometrial Neoplasms - pathology; Endometrium; Endometrium - pathology; Estrogens; Female; Humans; Hyperplasia; Metaplasia; Microscopy; Mutation; Pathology; PAX2 Transcription Factor - genetics; PTEN Phosphohydrolase - genetics; Reproducibility; Stains & staining
• ISSN: 0003-9985; 1543-2165; 1543-2165
• DOI: 10.5858/arpa.2012-0709-RA

Developed in conjunction with molecular and progression data, the sequence classification schema for endometrial intraepithelial neoplasia (EIN)/benign hyperplasia (BH) provides an easy to adopt and reproducible method for classification of endometrial biopsies.
To review current data supporting the use of BH/EIN to classify endometrial biopsies, and to discuss the hormone-driven endometrial sequence from anovulation/disordered proliferative endometrium through BH and EIN and their diagnostic difficulty.
A comprehensive review of EIN literature based on literature indexed by PubMed (National Library of Medicine) and Google Scholar.
The BH/EIN schema is gaining wider acceptance among pathologist and clinicians. The research leading to the EIN criteria is based on molecular and progression data. The BH/EIN schema has better reproducibility among pathologists, is intuitively easy to use, and requires understanding of endometrial physiology and neoplasia.