Effect of Ex Vivo Culture of CD34+ Bone Marrow Cells on Immune Reconstitution of XSCID Dogs Following Allogeneic Bone Marrow Transplantation

Successful genetic treatment of most primary immunodeficiencies or hematological disorders will require the transduction of pluripotent, self-renewing hematopoietic stem cells (HSC) rather than their progeny to achieve enduring production of genetically corrected cells and durable immune reconstitut...

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Bibliographic Details
Published in:	Biology of blood and marrow transplantation Vol. 15; no. 6; pp. 662 - 670
Main Authors:	Kennedy, Douglas R, McLellan, Kyle, Moore, Peter F, Henthorn, Paula S, Felsburg, Peter J
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2009
Subjects:	Animals Antigens, CD34 - analysis Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - virology Bone Marrow Transplantation Cell Culture Techniques - methods Cell Separation Cells, Cultured - drug effects Cells, Cultured - transplantation Disease Models, Animal Dog Dogs Ex vivo culture Genetic Therapy - methods Genetic Vectors - therapeutic use Graft Survival Hematology, Oncology and Palliative Medicine Hematopoietic Cell Growth Factors - pharmacology Hematopoietic Stem Cell Transplantation Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Interleukin Receptor Common gamma Subunit - deficiency Interleukin Receptor Common gamma Subunit - genetics Interleukin Receptor Common gamma Subunit - physiology Lentivirus - genetics Lymphocyte Activation Lymphocyte Subsets - pathology Recombinant Fusion Proteins - physiology Severe Combined Immunodeficiency - genetics Severe Combined Immunodeficiency - pathology Severe Combined Immunodeficiency - surgery Severe Combined Immunodeficiency - therapy Thymus Gland - pathology Time Factors Transplantation, Autologous X-linked SCID Bone marrow transplantation Ex vivo culture X-linked SCID Dog
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