Discharge properties of single neurons in the dorsal nucleus of the lateral lemniscus of the rat

• Published in: Brain research bulletin Vol. 47; no. 6; pp. 595 - 610
• Main Authors: Bajo, Victoria M, Villa, Alessandro E.P, de Ribaupierre, François, Rouiller, Eric M
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-12-1998; Elsevier Science
• Subjects: Acoustic Stimulation; Action Potentials - physiology; Animals; Auditory physiology; Auditory Threshold - physiology; Behavior, Animal - physiology; Biological and medical sciences; Brain stem; Brain Stem - cytology; Brain Stem - physiology; Central nervous system; Electrophysiology; Evoked Potentials, Auditory, Brain Stem - physiology; Extracellular single unit recording; Extracellular Space; Functional Laterality - physiology; Fundamental and applied biological sciences. Psychology; Membrane Potentials - physiology; Neurons - physiology; Noise; Rats; Rats, Wistar; Spontaneous activity; Vertebrates: nervous system and sense organs; Vestibulocochlear Nerve - cytology; Vestibulocochlear Nerve - physiology; Auditory physiology; Acoustic stimulation; Brain stem; Spontaneous activity; Extracellular single unit recording; Vertebrata; Mammalia; Acoustic stimulus; Rat; Rodentia; Central nervous system; Discharge pattern; Electrophysiology; Dorsal nucleus; Brain (vertebrata)
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/S0361-9230(98)00127-0

The aim of the present study was to characterize the discharge properties of single neurons in the dorsal nucleus of the lateral lemniscus (DNLL) of the rat. In the absence of acoustic stimulation, two types of spontaneous discharge patterns were observed: units tended to fire in a bursting or in a nonbursting mode. The distribution of units in the DNLL based on spontaneous firing rate followed a rostrocaudal gradient: units with high spontaneous rates were most commonly located in the rostral part of the DNLL, whereas in the caudal part units had lower spontaneous discharge rates. The most common response pattern of DNLL units to 200 ms binaural noise bursts contained a prominent onset response followed by a lower but steady-state response and an inhibitory response in the early-off period. Thresholds of response to noise bursts were on average higher for DNLL units than for units recorded in the inferior colliculus under the same experimental conditions. The DNLL units were arranged according to a mediolateral sensitivity gradient with the lowest threshold units in the most lateral part of the nucleus. In the rat, as in other mammals, the most common DNLL binaural input type was an excitatory response to contralateral ear stimulation and inhibitory response to ipsilateral ear stimulation (EI type). Pure tone bursts were in general a more effective stimulus compared to noise bursts. Best frequency (BF) was established for 97 DNLL units and plotted according to their spatial location. The DNLL exhibits a loose tonotopic organization, where there is a concentric pattern with high BF units located in the most dorsal and ventral parts of the DNLL and lower BF units in the middle part of the nucleus.