Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates

ABSTRACT Purpose To evaluate whether the impact of functional modulation of the breast cancer resistance protein (BCRP, ABCG2 421C>A) on human pharmacokinetics after oral administration is predictable using Bcrp knockout mice and cynomolgus monkeys pretreated with a BCRP inhibitor, elacridar. Met...

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Bibliographic Details
Published in:	Pharmaceutical research Vol. 32; no. 5; pp. 1634 - 1647
Main Authors:	Karibe, Tsuyoshi, Hagihara-Nakagomi, Rie, Abe, Koji, Imaoka, Tomoki, Mikkaichi, Tsuyoshi, Yasuda, Satoru, Hirouchi, Masakazu, Watanabe, Nobuaki, Okudaira, Noriko, Izumi, Takashi
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-05-2015 Springer Nature B.V
Subjects:	Acridines - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Breast cancer Caco-2 Cells Drug resistance Fatty Acids, Monounsaturated - administration & dosage Fatty Acids, Monounsaturated - blood Fatty Acids, Monounsaturated - pharmacokinetics Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Indoles - administration & dosage Indoles - blood Indoles - pharmacokinetics Intestinal Absorption - drug effects Kinetics Macaca fascicularis Male Medical Law Mice, Knockout Monkeys & apes Pharmacology Pharmacology/Toxicology Pharmacy Proteins Quinolines - administration & dosage Quinolines - blood Quinolines - pharmacokinetics Research Paper Rosuvastatin Calcium - administration & dosage Rosuvastatin Calcium - blood Rosuvastatin Calcium - pharmacokinetics Substrates Sulfasalazine - administration & dosage Sulfasalazine - blood Sulfasalazine - pharmacokinetics Tetrahydroisoquinolines - pharmacology 421C>A BCRP Gastrointestinal absorption Cynomolgus monkey Knockout mouse
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