Double Blinded Randomized Trial of Subcutaneous Trigeminal Nerve Stimulation as Adjuvant Treatment for Major Unipolar Depressive Disorder

Abstract BACKGROUND More than 30% of major depressive disorder patients fail to respond to adequate trials of medications and psychotherapy. While modern neuromodulation approaches (ie, vagal nerve stimulation, deep brain stimulation) are yet to prove their efficacy for such cases in large randomize...

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Bibliographic Details
Published in:	Neurosurgery Vol. 85; no. 5; pp. 717 - 728
Main Authors:	Gorgulho, Alessandra A, Fernandes, Fernando, Damiani, Lucas P, Barbosa, Daniel A N, Cury, Abrão, Lasagno, Camila M, Bueno, Priscila R T, Santos, Bruno F O, Santos, Renato H N, Berwanger, Otávio, Cavalcanti, Alexandre B, Teixeira, Manoel J, Moreno, Ricardo A, De Salles, Antonio A F
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01-11-2019 Copyright by the Congress of Neurological Surgeons Wolters Kluwer Health, Inc
Subjects:	Adult Antidepressants Care and treatment Chronic Disease - therapy Clinical trials Deep brain stimulation Depression, Mental Depressive Disorder, Major - therapy Depressive Disorder, Treatment-Resistant - therapy Double-Blind Method Electric Stimulation Therapy - methods Female Humans Male Medical colleges Mental depression Middle Aged Neurosurgery Patient compliance Placebo effect Product development Psychotherapy Research Design Treatment Outcome Trigeminal Nerve Brazil Trigeminal nerve stimulation Subcutaneous V1 stimulation Major depression Neuromodulation Treatment-resistant depression
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