Choice of dopaminergic therapy among early, mild Parkinson disease subjects in North America

• Published in: Journal of the neurological sciences Vol. 366; pp. 74 - 81
• Main Authors: Goudreau, John L, Pérez, Adriana, Aminoff, Michael J, Boyd, James T, Burau, Keith D, Christine, Chadwick W, Leehey, Maureen, Morgan, John C
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-07-2016
• Subjects: Age Factors; Aged; Antiparkinson Agents - therapeutic use; Canada - epidemiology; Choice Behavior; Clinical trial; Dopamine Agents - therapeutic use; Dopamine agonists; Educational Status; Female; Humans; Levodopa; Logistic Models; Male; Middle Aged; Monoamine Oxidase Inhibitors - therapeutic use; Multivariate Analysis; Neurology; Parkinson Disease - drug therapy; Parkinson Disease - epidemiology; Patient Acceptance of Health Care - statistics & numerical data; Time Factors; Treatment Outcome; United States - epidemiology; Dopamine agonists; Clinical trial; Levodopa
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2016.04.021

Abstract The choice of dopaminergic therapy in early Parkinson disease (PD) is an important clinical decision, yet factors influencing this decision have not been extensively studied. We sought to investigate the factors that may be associated with the choice of dopaminergic therapy at the NINDS Exploratory Trials in PD (NET-PD) Long-Term Study-1 (LS1). NET-PD LS1 was a clinical trial of creatine versus placebo in participants with early, mild PD on stable doses of dopaminergic therapy. Baseline data from 1616 out of the 1741 participants were evaluated using univariable and multivariable logistic or generalized logit regression analyses for available factors associated with the choice of dopaminergic therapy. The dopaminergic therapy choice was determined as: (i) therapy that subjects recalled taking 180 days before the study; (ii) therapy at baseline; and (iii) the longest duration of therapy reported by participants. Younger age, higher education level, longer length of time since PD diagnosis and use of an adjunctive, non-dopaminergic or monoamine oxidase inhibitor medication were associated with more frequent use of dopamine agonist compared to levodopa or combination therapy.