Cold-Induced Pseudoneutropenia in Human Immunodeficiency Virus Infection: First Case Report and Review of Related Articles

• Published in: Indian journal of hematology & blood transfusion Vol. 30; no. Suppl 1; pp. 148 - 150
• Main Authors: Goyal, Prashant, Agrawal, Dipti, Kailash, J., Singh, Sompal
• Format: Journal Article
• Language: English
• Published: India Springer India 01-09-2014; Springer Nature B.V
• Subjects: Blood platelets; Blood Transfusion Medicine; Case Report; Erythrocytes; Hematology; HIV; Human Genetics; Human immunodeficiency virus; Medicine; Medicine & Public Health; Oncology; HIV; EDTA; Cold agglutination; Pseudoneutropenia; Neutrophil agglutination
• ISSN: 0971-4502; 0974-0449; 0974-0449; 0971-4502
• DOI: 10.1007/s12288-013-0300-1

Cold agglutination of erythrocyte or platelet aggregation in vitro due to cold agglutination are well recognized and extensively studied. Aggregation of leucocyte is a rare hematological phenomenon resulting in a spurious low leucocyte count performed using automated hematology analyzers. Aggregation of leucocyte may relate to malignancy, lymphoproliferative disorders, infection, liver diseases, or autoimmune disorders. It is believed that the mechanism of leucocyte aggregation is mainly related to the use of ethylene diamine tetraacetic acid (EDTA) anticoagulant or is temperature-mediated. Leucoagglutination is associated with either a spurious leucopenia or an underestimation of leucocytosis. This can adversely affect management decisions in terms of unnecessary management of leucopenia or ignoring a leucocytosis that may be indicator of an underlying serious disease. To our knowledge, we report here for the first time the occurrence of pseudoneutropenia due to temperature-mediated, EDTA-independent neutrophil agglutination in adult with human immunodeficiency virus infection.