Dysplastic Leukoplakia

To the Editor: The article by Sudbø and colleagues (April 1 issue) 1 advances the understanding of dysplastic oral leukoplakia, but the suggestion that surgical removal is ineffective in preventing oral carcinoma is highly debatable. There is agreement that advanced dysplasia appears to be incurable...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 350; no. 26; pp. 2718 - 2719
Main Author:	Damm, Douglas D
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 24-06-2004
Subjects:	Aneuploidy Humans Leukoplakia, Oral - complications Leukoplakia, Oral - surgery Mouth Neoplasms - etiology Mouth Neoplasms - prevention & control Neoplasm Staging Recurrence
Online Access:	Get full text
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Summary:	To the Editor: The article by Sudbø and colleagues (April 1 issue) 1 advances the understanding of dysplastic oral leukoplakia, but the suggestion that surgical removal is ineffective in preventing oral carcinoma is highly debatable. There is agreement that advanced dysplasia appears to be incurable in many patients, and recurrences are common. Although the adjacent epithelium appears to be normal on clinical and microscopical examination, it most likely is altered genetically and destined to become dysplastic within a few cell generations. The study cohort was evaluated every six months, and many lesions were followed without biopsy if the clinical presentation did . . .
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM200406243502619