Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma

We investigated the effect of carbonic anhydrase IX (CA IX) inhibitor under hypoxia and normoxia in SaOS2 human osteosarcoma cell line. We also evaluated the expression of CA IX in 27 patients diagnosed with osteosarcoma. CA IX expression in SaOS2 cells cultured under different oxygen tensions was a...

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Bibliographic Details
Published in:	OncoTargets and therapy Vol. 11; pp. 6879 - 6886
Main Authors:	Okuno, Kazuma, Matsubara, Takao, Nakamura, Tomoki, Iino, Takahiro, Kakimoto, Takuya, Asanuma, Kunihiro, Matsumine, Akihiko, Sudo, Akihiro
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01-01-2018 Taylor & Francis Ltd Dove Medical Press
Subjects:	Analysis Anthracyclines Bone cancer Bone surgery Breast cancer Cancer therapies Carbonic anhydrases Cell adhesion & migration Cell culture Cell cycle Cell growth Cell viability Chemotherapy Development and progression Health aspects Hypoxia Immunohistochemistry Medical prognosis Metastasis Original Research Orthopedics Osteosarcoma Proteins Sarcoma Tumors United Kingdom > UK United States > US Japan hypoxia carbonic anhydrase IX inhibitor osteosarcoma
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