Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma

Hypoxia is a common feature of solid tumors, which controls multiple aspects of cancer progression. One important function of hypoxia and the hypoxia-inducible factors (HIF) is the maintenance of cancer stem-like cells (CSC), a population of tumor cells that possess stem cell-like properties and dri...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 76; no. 19; pp. 5845 - 5856
Main Authors:	Filatova, Alina, Seidel, Sascha, Böğürcü, Nuray, Gräf, Sabine, Garvalov, Boyan K, Acker, Till
Format:	Journal Article
Language:	English
Published:	United States 01-10-2016
Subjects:	Acidosis - metabolism Animals Basic Helix-Loop-Helix Transcription Factors - physiology Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Female Glioma - metabolism Glioma - pathology HSP90 Heat-Shock Proteins - physiology Humans Hydrogen-Ion Concentration Hypoxia-Inducible Factor 1, alpha Subunit - physiology Mice Neoplastic Stem Cells - physiology Prolyl Hydroxylases - physiology Von Hippel-Lindau Tumor Suppressor Protein - physiology
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