Clinical spectrum of Kawasaki disease in infants younger than 6 months of age

• Published in: The Journal of pediatrics Vol. 109; no. 5; p. 759
• Main Authors: Burns, J C, Wiggins, Jr, J W, Toews, W H, Newburger, J W, Leung, D Y, Wilson, H, Glodé, M P
• Format: Journal Article
• Language: English
• Published: United States 01-11-1986
• Subjects: Aspirin - administration & dosage; Aspirin - therapeutic use; Coronary Aneurysm - diagnosis; Coronary Aneurysm - etiology; Coronary Aneurysm - mortality; Coronary Aneurysm - pathology; Dipyridamole; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Fever - etiology; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome - diagnosis; Mucocutaneous Lymph Node Syndrome - mortality; Mucocutaneous Lymph Node Syndrome - pathology; Myocardium - pathology; Risk; Warfarin - therapeutic use
• ISSN: 0022-3476
• DOI: 10.1016/s0022-3476(86)80689-8

We report an unselected series of eight patients younger than 6 months of age with Kawasaki disease evaluated between January 1982 and May 1984. The incidence of coronary artery aneurysms (six patients) and the mortality (two patients) were unusually high in this small series. Because of the confusing clinical presentation in three patients, diagnosis was delayed until pathologic or echocardiographic evidence of coronary vasculitis or aneurysm was discovered. The currently accepted clinical criteria for Kawasaki disease may not always identify patients with the pathologic findings of the syndrome who are younger than 6 months of age. The diagnosis of Kawasaki disease and echocardiographic evaluation of the coronary arteries should be considered in young infants with prolonged fever of unknown origin.