HIV-1 Persistence and Chronic Induction of Innate Immune Responses in Macrophages

A hallmark of HIV-1 infection is chronic inflammation, which plays a significant role in disease pathogenesis. Acute HIV infection induces robust inflammatory responses, which are insufficient to prevent or eliminate virus in mucosal tissues. While establishment of viral set-point is coincident with...

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Bibliographic Details
Published in:	Viruses Vol. 12; no. 7; p. 711
Main Authors:	Akiyama, Hisashi, Gummuluru, Suryaram
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 30-06-2020 MDPI AG
Subjects:	Animals Anti-HIV Agents - pharmacology CD4-Positive T-Lymphocytes - immunology chronic innate immune activation HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology Humans Immunity, Innate intron-containing RNA macrophage Macrophages - immunology PAMPs persistent viral RNA expression Review persistent viral RNA expression PAMPs macrophage chronic innate immune activation HIV intron-containing RNA
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