Diverging fates of cells of origin in acute and chronic leukaemia

The large difference in phenotypes among tumour populations may stem from the stochastic origin of tumours from distinct cells – tumour cells are assumed to retain the phenotypes of the cells from which they derive. Yet, functional studies addressing the cellular origin of leukaemia are lacking. Her...

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Bibliographic Details
Published in:	EMBO molecular medicine Vol. 4; no. 4; pp. 283 - 297
Main Authors:	Kovacic, Boris, Hoelbl, Andrea, Litos, Gabriele, Alacakaptan, Memetcan, Schuster, Christian, Fischhuber, Katrin M., Kerenyi, Marc A., Stengl, Gabriele, Moriggl, Richard, Sexl, Veronika, Beug, Hartmut
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-04-2012 WILEY‐VCH Verlag EMBO Press WILEY-VCH Verlag
Subjects:	Abl gene Acute lymphoblastic leukemia B-Lymphocytes - cytology B-Lymphocytes - metabolism B-Lymphocytes - pathology BCR gene BCR protein B‐lymphoid differentiation Cancer cancer stem cells Cell differentiation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology cells of origin of cancer Cloning Genotype & phenotype Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humans leukaemia Leukemia Leukemia, Basophilic, Acute - metabolism Leukemia, Basophilic, Acute - pathology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Lymphocytes B Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phenotypes Research Article Stat5 protein STAT5 Transcription Factor - metabolism Stem cells Stochasticity cells of origin of cancer B‐lymphoid differentiation leukaemia cancer cancer stem cells
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