Decidual natural killer cells regulate vessel stability: implications for impaired spiral artery remodelling

• Published in: Journal of reproductive immunology Vol. 110; pp. 54 - 60
• Main Authors: Fraser, Rupsha, Whitley, Guy St.J, Thilaganathan, Baskaran, Cartwright, Judith E
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-08-2015; Elsevier/North-Holland Biomedical Press
• Subjects: Adult; Arteries - diagnostic imaging; Arteries - immunology; Cell Line, Transformed; Decidua; Decidua - blood supply; Decidua - diagnostic imaging; Decidua - immunology; Endothelium; Endothelium, Vascular - diagnostic imaging; Endothelium, Vascular - immunology; Female; Humans; Killer Cells, Natural - diagnostic imaging; Killer Cells, Natural - immunology; Natural killer; Obstetrics and Gynecology; Placenta - blood supply; Placenta - diagnostic imaging; Placenta - immunology; Pre-eclampsia; Pre-Eclampsia - diagnostic imaging; Pre-Eclampsia - immunology; Pregnancy; Pregnancy Trimester, First - immunology; Remodelling; Spiral artery; Ultrasonography; Remodelling; Pre-eclampsia; Spiral artery; Decidua; Natural killer; Endothelium
• ISSN: 0165-0378; 1872-7603
• DOI: 10.1016/j.jri.2015.04.003

Highlights • dNK cells isolated from pregnancies with high or normal uterine artery resistance indices. • Normal-RI dNK cells activate ECs and destabilise endothelial tube-like structures. • Normal-RI dNK cells induce more TNFα production from ECs than high-RI dNK cells. • TNFα destabilises endothelial tube-like structures.