Paraneoplastic cutaneous manifestations: concepts and updates

• Published in: Anais brasileiros de dermatología Vol. 88; no. 1; pp. 9 - 22
• Main Authors: Silva, Josenilson Antônio da, Mesquita, Kleyton de Carvalho, Igreja, Ana Carolina de Souza Machado, Lucas, Isabella Cristina Rodrigues Naves, Freitas, Aline Ferreira, Oliveira, Sandra Maximiano de, Costa, Izelda Maria Carvalho, Campbell, Iphis Tenfuss
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Dermatologia 01-01-2013
• Subjects: Continued Medical Education; DERMATOLOGY; Education, Medical, Continuing; Humans; Necrosis; Paraneoplastic Syndromes - complications; Paraneoplastic Syndromes - pathology; Prognosis; Skin Diseases - etiology; Skin Diseases - pathology; Surveys and Questionnaires; Manifestações cutâneas; Neoplasias; Paraneoplastic syndromes; Skin manifestations; Síndromes paraneoplásicas; Neoplasms
• ISSN: 0365-0596; 1806-4841; 1806-4841; 0365-0596
• DOI: 10.1590/s0365-05962013000100001

The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trélat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis.