CsbZIP1-CsMYB12 mediates the production of bitter-tasting flavonols in tea plants (Camellia sinensis) through a coordinated activator–repressor network
Under high light conditions or UV radiation, tea plant leaves produce more flavonols, which contribute to the bitter taste of tea; however, neither the flavonol biosynthesis pathways nor the regulation of their production are well understood. Intriguingly, tea leaf flavonols are enhanced by UV-B but...
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| Published in: | Horticulture research Vol. 8; no. 1 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Nature Publishing Group UK
01-05-2021
Oxford University Press |
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| Abstract | Under high light conditions or UV radiation, tea plant leaves produce more flavonols, which contribute to the bitter taste of tea; however, neither the flavonol biosynthesis pathways nor the regulation of their production are well understood. Intriguingly, tea leaf flavonols are enhanced by UV-B but reduced by shading treatment.
CsFLS
,
CsUGT78A14, CsMYB12
, and
CsbZIP1
were upregulated by UV-B radiation and downregulated by shading. CsMYB12 and CsbZIP1 bound to the promoters of
CsFLS
and
CsUGT78A14
, respectively, and activated their expression individually. CsbZIP1 positively regulated
CsMYB12
and interacted with CsMYB12, which specifically activated flavonol biosynthesis. Meanwhile,
CsPIF3
and two MYB repressor genes,
CsMYB4
and
CsMYB7
, displayed expression patterns opposite to that of
CsMYB12
. CsMYB4 and CsMYB7 bound to
CsFLS
and
CsUGT78A14
and repressed their CsMYB12-activated expression. While CsbZIP1 and CsMYB12 regulated neither
CsMYB4
nor
CsMYB7
, CsMYB12 interacted with CsbZIP1, CsMYB4, and CsMYB7, but CsbZIP1 did not physically interact with CsMYB4 or CsMYB7. Finally, CsPIF3 bound to and activated
CsMYB7
under shading to repress flavonol biosynthesis. These combined results suggest that UV activation and shading repression of flavonol biosynthesis in tea leaves are coordinated through a complex network involving
CsbZIP1
and
CsPIF3
as positive MYB activators and negative MYB repressors, respectively. The study thus provides insight into the regulatory mechanism underlying the production of bitter-tasting flavonols in tea plants. |
|---|---|
| AbstractList | Under high light conditions or UV radiation, tea plant leaves produce more flavonols, which contribute to the bitter taste of tea; however, neither the flavonol biosynthesis pathways nor the regulation of their production are well understood. Intriguingly, tea leaf flavonols are enhanced by UV-B but reduced by shading treatment.
CsFLS
,
CsUGT78A14, CsMYB12
, and
CsbZIP1
were upregulated by UV-B radiation and downregulated by shading. CsMYB12 and CsbZIP1 bound to the promoters of
CsFLS
and
CsUGT78A14
, respectively, and activated their expression individually. CsbZIP1 positively regulated
CsMYB12
and interacted with CsMYB12, which specifically activated flavonol biosynthesis. Meanwhile,
CsPIF3
and two MYB repressor genes,
CsMYB4
and
CsMYB7
, displayed expression patterns opposite to that of
CsMYB12
. CsMYB4 and CsMYB7 bound to
CsFLS
and
CsUGT78A14
and repressed their CsMYB12-activated expression. While CsbZIP1 and CsMYB12 regulated neither
CsMYB4
nor
CsMYB7
, CsMYB12 interacted with CsbZIP1, CsMYB4, and CsMYB7, but CsbZIP1 did not physically interact with CsMYB4 or CsMYB7. Finally, CsPIF3 bound to and activated
CsMYB7
under shading to repress flavonol biosynthesis. These combined results suggest that UV activation and shading repression of flavonol biosynthesis in tea leaves are coordinated through a complex network involving
CsbZIP1
and
CsPIF3
as positive MYB activators and negative MYB repressors, respectively. The study thus provides insight into the regulatory mechanism underlying the production of bitter-tasting flavonols in tea plants. Under high light conditions or UV radiation, tea plant leaves produce more flavonols, which contribute to the bitter taste of tea; however, neither the flavonol biosynthesis pathways nor the regulation of their production are well understood. Intriguingly, tea leaf flavonols are enhanced by UV-B but reduced by shading treatment. CsFLS, CsUGT78A14, CsMYB12, and CsbZIP1 were upregulated by UV-B radiation and downregulated by shading. CsMYB12 and CsbZIP1 bound to the promoters of CsFLS and CsUGT78A14, respectively, and activated their expression individually. CsbZIP1 positively regulated CsMYB12 and interacted with CsMYB12, which specifically activated flavonol biosynthesis. Meanwhile, CsPIF3 and two MYB repressor genes, CsMYB4 and CsMYB7, displayed expression patterns opposite to that of CsMYB12. CsMYB4 and CsMYB7 bound to CsFLS and CsUGT78A14 and repressed their CsMYB12-activated expression. While CsbZIP1 and CsMYB12 regulated neither CsMYB4 nor CsMYB7, CsMYB12 interacted with CsbZIP1, CsMYB4, and CsMYB7, but CsbZIP1 did not physically interact with CsMYB4 or CsMYB7. Finally, CsPIF3 bound to and activated CsMYB7 under shading to repress flavonol biosynthesis. These combined results suggest that UV activation and shading repression of flavonol biosynthesis in tea leaves are coordinated through a complex network involving CsbZIP1 and CsPIF3 as positive MYB activators and negative MYB repressors, respectively. The study thus provides insight into the regulatory mechanism underlying the production of bitter-tasting flavonols in tea plants. |
| ArticleNumber | 110 |
| Author | Fernie, Alisdair R. Zhao, Jian Zeng, Xiangsheng Zhao, Xuecheng Lin, Ning Yu, Shuwei |
| Author_xml | – sequence: 1 givenname: Xuecheng surname: Zhao fullname: Zhao, Xuecheng organization: State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University – sequence: 2 givenname: Xiangsheng surname: Zeng fullname: Zeng, Xiangsheng organization: College of Agronomy, Anhui Agricultural University – sequence: 3 givenname: Ning surname: Lin fullname: Lin, Ning organization: State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University – sequence: 4 givenname: Shuwei surname: Yu fullname: Yu, Shuwei organization: State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University – sequence: 5 givenname: Alisdair R. orcidid: 0000-0001-9000-335X surname: Fernie fullname: Fernie, Alisdair R. organization: Max-Planck-Institute of Molecular Plant Physiology – sequence: 6 givenname: Jian orcidid: 0000-0002-4416-7334 surname: Zhao fullname: Zhao, Jian email: jzhao2@qq.com organization: State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University |
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| Snippet | Under high light conditions or UV radiation, tea plant leaves produce more flavonols, which contribute to the bitter taste of tea; however, neither the... |
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| SubjectTerms | 631/449/2667 631/449/2686 Agriculture Biomedical and Life Sciences Biosynthesis Bitter taste Ecology Flavonols Leaves Life Sciences Plant Breeding/Biotechnology Plant Genetics and Genomics Plant Sciences Regulatory mechanisms (biology) Repressors Shading Tea Ultraviolet radiation |
| Title | CsbZIP1-CsMYB12 mediates the production of bitter-tasting flavonols in tea plants (Camellia sinensis) through a coordinated activator–repressor network |
| URI | https://link.springer.com/article/10.1038/s41438-021-00545-8 https://www.proquest.com/docview/2520052886 https://pubmed.ncbi.nlm.nih.gov/PMC8087823 |
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