Estimation of the Burden of Iron Deficiency Anemia in France from Iron Intake: Methodological Approach

• Published in: Nutrients Vol. 11; no. 9; p. 2045
• Main Authors: Mota, Juliana De Oliveira, Tounian, Patrick, Guillou, Sandrine, Pierre, Fabrice, Membré, Jeanne-Marie
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-09-2019; MDPI
• Subjects: Adolescent; Adult; Age; Anemia; Anemia, Iron-Deficiency - epidemiology; Anemia, Iron-Deficiency - etiology; Bioavailability; Blood levels; Cancer; Cardiovascular disease; Child; Children; Computer simulation; Cost of Illness; DALY; Diabetes; Female; Ferritin; Food; Food and Nutrition; France - epidemiology; Health risk assessment; Health risks; Hematology; Hemoglobin; Human health and pathology; Humans; Intelligence; Iron; iron deficiency; Iron, Dietary - analysis; Life Sciences; Male; Males; Meat; Models, Statistical; Mortality; Nutrient deficiency; Nutrition; Nutritional Status; Population; Prevalence; probabilistic model; Quotients; Risk analysis; risk assessment; Risk Factors; Santé publique et épidémiologie; second-order Monte Carlo simulation; Vegetarianism; Womens health; Zoonoses; France; risk assessment; second-order Monte Carlo simulation; iron deficiency; DALY; anemia; probabilistic model
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11092045

Dietary iron deficiency (ID) is the first nutritional deficiency in the world, in terms of disability adjusted life years (DALY). This nutritional deficiency may lead to anemia, especially among children, adolescents, and adult women. The aim of this study was to build an original probabilistic model to quantitatively assess the ID, the iron deficiency anemia (IDA) and the subsequent health burden in France expressed in DALY, per age class and gender. The model considered the distribution of absorbed iron intake, the iron requirement distribution established by the European Food Safety Authority and the iron status in France. Uncertainty due to lack of data and variability due to biological diversity were taken into account and separated using a second-order Monte Carlo procedure. A total of 1290 (95% CI = 1230-1350) IDA cases corresponding to 16 (95% CI = 11-20) DALY were estimated per 100,000 individuals per year. The major contributors to IDA burden were menstruating females aged from 25 to 44 years old. Then, a consumption scenario was built with ground beef as intake, an increase in red meat consumption to 100 g/d would not eliminate entirely the IDA burden. The quantitative methodology applied here for France could be reused for other populations.