Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat

The long-term behaviour of cellulose sponge implants, 10×10×5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation....

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Published in:	Biomaterials Vol. 20; no. 21; pp. 1989 - 1995
Main Authors:	Märtson, Matis, Viljanto, Jouko, Hurme, Timo, Laippala, Pekka, Saukko, Pekka
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-11-1999 Elsevier Science
Subjects:	Absorbable Implants Animals Biocompatibile material Biocompatibility Biocompatible Materials Biodegradation, Environmental Biological and medical sciences Cellulose Connective tissue Drug Stability Foamed plastics Granulation tissue Implants, Artificial Implants, Experimental Male Medical sciences Pore size Rat, Sprague–Dawley Rats Rats, Sprague-Dawley Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tissue Granulation tissue Connective tissue Implants, Artificial Biocompatibile material Rat, Sprague–Dawley Cellulose Rat Biodegradability Rodentia Histology Long term In vivo Implanted material Vertebrata Mammalia Animal Surgery Biocompatibility Sponge
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Abstract	The long-term behaviour of cellulose sponge implants, 10×10×5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically, moderate foreign body tissue reaction inside the implant, the appearance of cracks and fissures, spotty colouration, and softening of the pore walls were observed up to 16 weeks after implantation. Later, the foreign body reaction inside the sponge became milder, the spotty colouration disappeared and micropores enlarged in the viscose cellulose matrix. Histomorphometrically, the cross-sectional area of the implants and the size of the pore wall fragments decreased, and the number of pore wall fragments increased significantly. The cellulose sponge used can be regarded as a slowly degradable implantation material. However, the time needed for the total disappearance of the cellulose sponge from subcutaneous tissue is longer than the 60 weeks.
AbstractList	The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat for 1-60 weeks after implantation. The cellulose sponge was filled with connective tissue within 4-8 weeks after implantation. Moderate foreign body tissue reaction inside the implant was observed up to 16 weeks after implantation. The cellulose sponge can be regarded as a slowly degradable implantation material; however, the time needed for the total disappearance of sponge from subcutaneous tissue is longer than the 60 weeks allowed in this study. (Original abstract - amended) The long-term behaviour of cellulose sponge implants, 10×10×5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically, moderate foreign body tissue reaction inside the implant, the appearance of cracks and fissures, spotty colouration, and softening of the pore walls were observed up to 16 weeks after implantation. Later, the foreign body reaction inside the sponge became milder, the spotty colouration disappeared and micropores enlarged in the viscose cellulose matrix. Histomorphometrically, the cross-sectional area of the implants and the size of the pore wall fragments decreased, and the number of pore wall fragments increased significantly. The cellulose sponge used can be regarded as a slowly degradable implantation material. However, the time needed for the total disappearance of the cellulose sponge from subcutaneous tissue is longer than the 60 weeks. The long-term behaviour of cellulose sponge implants, 10x10x5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically, moderate foreign body tissue reaction inside the implant, the appearance of cracks and fissures, spotty colouration, and softening of the pore walls were observed up to 16 weeks after implantation. Later, the foreign body reaction inside the sponge became milder, the spotty colouration disappeared and micropores enlarged in the viscose cellulose matrix. Histomorphometrically, the cross-sectional area of the implants and the size of the pore wall fragments decreased, and the number of pore wall fragments increased significantly. The cellulose sponge used can be regarded as a slowly degradable implantation material. However, the time needed for the total disappearance of the cellulose sponge from subcutaneous tissue is longer than the 60 weeks. The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically, moderate foreign body tissue reaction inside the implant, the appearance of cracks and fissures, spotty colouration, and softening of the pore walls were observed up to 16 weeks after implantation. Later, the foreign body reaction inside the sponge became milder, the spotty colouration disappeared and micropores enlarged in the viscose cellulose matrix. Histomorphometrically, the cross-sectional area of the implants and the size of the pore wall fragments decreased, and the number of pore wall fragments increased significantly. The cellulose sponge used can be regarded as a slowly degradable implantation material. However, the time needed for the total disappearance of the cellulose sponge from subcutaneous tissue is longer than the 60 weeks.
Author	Hurme, Timo Märtson, Matis Saukko, Pekka Viljanto, Jouko Laippala, Pekka
Author_xml	– sequence: 1 givenname: Matis surname: Märtson fullname: Märtson, Matis email: matmar@utu.fi organization: Departments of Paediatric Surgery, University of Turku, FIN-20520 Turku, Finland – sequence: 2 givenname: Jouko surname: Viljanto fullname: Viljanto, Jouko organization: Departments of Paediatric Surgery, University of Turku, FIN-20520 Turku, Finland – sequence: 3 givenname: Timo surname: Hurme fullname: Hurme, Timo organization: Departments of Paediatric Surgery, University of Turku, FIN-20520 Turku, Finland – sequence: 4 givenname: Pekka surname: Laippala fullname: Laippala, Pekka organization: Tampere School of Public Health, University of Tampere and Tampere University Hospital, POB 607, FIN-33101 Tampere, Finland – sequence: 5 givenname: Pekka surname: Saukko fullname: Saukko, Pekka organization: Forensic Medicine, University of Turku, FIN-20520 Turku, Finland
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Keywords	Granulation tissue Connective tissue Implants, Artificial Biocompatibile material Rat, Sprague–Dawley Cellulose Rat Biodegradability Rodentia Histology Long term In vivo Implanted material Vertebrata Mammalia Animal Surgery Biocompatibility Sponge
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Snippet	The long-term behaviour of cellulose sponge implants, 10×10×5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of... The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue... The long-term behaviour of cellulose sponge implants, 10x10x5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of...
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StartPage	1989
SubjectTerms	Absorbable Implants Animals Biocompatibile material Biocompatibility Biocompatible Materials Biodegradation, Environmental Biological and medical sciences Cellulose Connective tissue Drug Stability Foamed plastics Granulation tissue Implants, Artificial Implants, Experimental Male Medical sciences Pore size Rat, Sprague–Dawley Rats Rats, Sprague-Dawley Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tissue
Title	Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat
URI	https://dx.doi.org/10.1016/S0142-9612(99)00094-0 https://www.ncbi.nlm.nih.gov/pubmed/10535810 https://search.proquest.com/docview/21448911 https://search.proquest.com/docview/27113723
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