Recent advances in the monitoring, modelling and control of crystallization systems

• Published in: Chemical engineering research & design Vol. 91; no. 10; pp. 1903 - 1922
• Main Authors: Nagy, Zoltan K., Fevotte, Gilles, Kramer, Herman, Simon, Levente L.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-10-2013; Elsevier
• Subjects: Chemical and Process Engineering; Chemical engineering; Controllability; Crystal structure; Crystallization; Crystallization control; Crystallization modelling; Crystallization monitoring; Crystallization review; Design engineering; Engineering Sciences; Modelling; Monitoring; Population balance modelling; Process analytical technologies; Population balance modelling; Process analytical technologies; Crystallization modelling; Crystallization monitoring; Crystallization review; Crystallization control
• ISSN: 0263-8762; 1744-3563
• DOI: 10.1016/j.cherd.2013.07.018

•Recent trends in population balance modelling of crystallization are described.•Overview of monitoring systems with emphasis on image analysis is provided.•Advances in model-based, model-free and statistical process control are presented.
Crystallization is one of the most important unit operations used for the separation and purification of crystalline solid products. Appropriate design and control of the crystallization process is paramount to produce crystalline products with tailor-made-properties. This paper provides an overview of selected recent developments in the modelling, monitoring and control of crystallization processes. We consider the topics discussed in this review to be enabling technologies for the development of the next generation of crystallization processes with significantly improved predictability, robustness and controllability.