Long-term epilepsy associated-tumors (LEATs): what is new?

• Published in: Arquivos de neuro-psiquiatria Vol. 81; no. 12; pp. 1146 - 1151
• Main Author: Rosemberg, Sergio
• Format: Journal Article
• Language: English
• Published: Germany Arquivos de Neuro-Psiquiatria 01-12-2023; Academia Brasileira de Neurologia - ABNEURO; Academia Brasileira de Neurologia (ABNEURO)
• Subjects: 2-Methylisoborneol; Astrocitoma; Astrocytoma; Brain cancer; Brain Neoplasms; Brain tumors; Epilepsia; Epilepsy; Glioma; Localization; Neoplasias Encefálicas; Neoplasias Neuroepiteliomatosas; Neoplasms, Neuroepithelial; NEUROSCIENCES; Neurosurgery; PSYCHIATRY; Tumors; Young adults; Neoplasias Encefálicas; Epilepsia; Epilepsy; Neoplasms, Neuroepithelial; Astrocitoma; Neoplasias Neuroepiteliomatosas; Astrocytoma; Brain Neoplasms
• ISSN: 0004-282X; 1678-4227; 1678-4227
• DOI: 10.1055/s-0043-1777730

Long-term epilepsy-associated tumors (LEATs) include a series of neoplasms that commonly occur in children, adolescents, or young adults, have an astrocytic or glioneuronal lineage, are histologically benign (WHO grade1) with a neocortical localization predominantly situated in the temporal lobes. Clinically, chronic refractory epilepsy is usually the unique symptom. Gangliogliomas (GG) and dysembryoplastic neuroepithelial tumors (DNT) are the most common representative entities besides pilocytic astrocytomas (PA) and angiocentric gliomas (AG). Recent molecular studies have defined new clinicopathological entities, which are recognized by the WHO 2021 classification of brain tumors. Some of them such as diffuse astrocytoma
or
altered, polymorphous low-grade neuroepithelial tumor of the young (PLNTY), and multilocular and vacuolating neuronal tumor (MVNT) are currently considered LEATs. The relationship between LEATs and epilepsy is still a matter of debate, and there is a general agreement about the beneficial effects of an early neurosurgical intervention on the clinical outcome.