COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
Abstract A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release....
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| Published in: | Journal of antimicrobial chemotherapy Vol. 75; no. 7; pp. 1667 - 1670 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Oxford University Press
01-07-2020
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| Abstract | Abstract
A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression. |
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| AbstractList | A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression. Abstract A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. There is an urgent need to identify safe and effective drugs for treatment. Chloroquine (CQ) exhibits a promising inhibitory effect. However, the clinical use of CQ can cause severe side effects. We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. It has a safer clinical profile and is suitable for those who are pregnant. It is cheaper and more readily available in China. We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression. |
| Author | Dai, Sheng-Ming Tong, Qiang Zhou, Dan |
| AuthorAffiliation | d2 Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University , Shanghai, China d3 Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital , Shanghai, China d1 Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University , Shanghai, China |
| AuthorAffiliation_xml | – name: d2 Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University , Shanghai, China – name: d3 Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital , Shanghai, China – name: d1 Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University , Shanghai, China |
| Author_xml | – sequence: 1 givenname: Dan orcidid: 0000-0002-2306-3456 surname: Zhou fullname: Zhou, Dan organization: Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China – sequence: 2 givenname: Sheng-Ming surname: Dai fullname: Dai, Sheng-Ming organization: Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China – sequence: 3 givenname: Qiang surname: Tong fullname: Tong, Qiang email: jasontong1985@outlook.com organization: Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32196083$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1186/1743-422X-2-69 10.1186/ar2764 10.1186/s40425-018-0343-9 10.1136/annrheumdis-2016-210927 10.1001/jama.2020.1585 10.1038/s41422-020-0282-0 10.1038/nature07405 10.4049/jimmunol.1000702 10.1084/jem.20051696 10.1136/ard.2008.101766 10.4049/jimmunol.1402793 10.3899/jrheum.161063 10.1038/s41584-018-0111-8 10.1161/CIRCULATIONAHA.111.089268 10.1002/1529-0131(199902)42:2<357::AID-ANR19>3.0.CO;2-J 10.1126/scitranslmed.aal3653 10.1186/s13075-017-1393-y 10.1002/prp2.293 10.1093/emboj/17.21.6230 10.1016/j.virusres.2014.11.021 10.1007/s11427-020-1637-5 10.1038/348600a0 10.1038/s41584-020-0372-x |
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| References | 32361760 - J Antimicrob Chemother. 2020 Jul 1;75(7):2016-2017 Wang (2020061904534695300_dkaa114-B2) 2020 Ewald (2020061904534695300_dkaa114-B11) 2008; 456 Xu (2020061904534695300_dkaa114-B1) 2020; 63 An (2020061904534695300_dkaa114-B14) 2015; 194 Furst (2020061904534695300_dkaa114-B24) 1999 Wu (2020061904534695300_dkaa114-B8) 2017; 19 Vincent (2020061904534695300_dkaa114-B15) 2005; 2 van den Borne (2020061904534695300_dkaa114-B9) 1997; 24 Lotteau (2020061904534695300_dkaa114-B7) 1990; 348 Lisney (2020061904534695300_dkaa114-B23) 2017; 76 Hacker (2020061904534695300_dkaa114-B12) 1998; 17 Ruiz-Irastorza (2020061904534695300_dkaa114-B6) 2010; 69 Ruiz-Irastorza (2020061904534695300_dkaa114-B19) 2009; 11 Srinivasa (2020061904534695300_dkaa114-B20) 2017; 44 Jorge (2020061904534695300_dkaa114-B21) 2018; 14 Shimabukuro-Vornhagen (2020061904534695300_dkaa114-B3) 2018; 6 Schrezenmeier (2020061904534695300_dkaa114-B17) 2020; 16 Millet (2020061904534695300_dkaa114-B16) 2015; 202 Wang (2020061904534695300_dkaa114-B4) 2020 Vollmer (2020061904534695300_dkaa114-B13) 2005; 202 Sheahan (2020061904534695300_dkaa114-B5) 2017; 9 Izmirly (2020061904534695300_dkaa114-B22) 2012; 126 Al-Bari (2020061904534695300_dkaa114-B18) 2017; 5 Kuznik (2020061904534695300_dkaa114-B10) 2011; 186 |
| References_xml | – volume: 2 start-page: 69 year: 2005 ident: 2020061904534695300_dkaa114-B15 article-title: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread publication-title: Virol J doi: 10.1186/1743-422X-2-69 contributor: fullname: Vincent – volume: 24 start-page: 55 year: 1997 ident: 2020061904534695300_dkaa114-B9 article-title: Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells publication-title: J Rheumatol contributor: fullname: van den Borne – volume: 11 start-page: R109 year: 2009 ident: 2020061904534695300_dkaa114-B19 article-title: Predictors of major infections in systemic lupus erythematosus publication-title: Arthritis Res Ther doi: 10.1186/ar2764 contributor: fullname: Ruiz-Irastorza – volume: 6 start-page: 56 year: 2018 ident: 2020061904534695300_dkaa114-B3 article-title: Cytokine release syndrome publication-title: J Immunother Cancer doi: 10.1186/s40425-018-0343-9 contributor: fullname: Shimabukuro-Vornhagen – volume: 76 start-page: 1476 year: 2017 ident: 2020061904534695300_dkaa114-B23 article-title: High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-210927 contributor: fullname: Lisney – year: 2020 ident: 2020061904534695300_dkaa114-B2 article-title: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China publication-title: JAMA doi: 10.1001/jama.2020.1585 contributor: fullname: Wang – start-page: 269 year: 2020 ident: 2020061904534695300_dkaa114-B4 article-title: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro publication-title: Cell Res doi: 10.1038/s41422-020-0282-0 contributor: fullname: Wang – volume: 456 start-page: 658 year: 2008 ident: 2020061904534695300_dkaa114-B11 article-title: The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor publication-title: Nature doi: 10.1038/nature07405 contributor: fullname: Ewald – volume: 186 start-page: 4794 year: 2011 ident: 2020061904534695300_dkaa114-B10 article-title: Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines publication-title: J Immunol doi: 10.4049/jimmunol.1000702 contributor: fullname: Kuznik – volume: 202 start-page: 1575 year: 2005 ident: 2020061904534695300_dkaa114-B13 article-title: Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8 publication-title: J Exp Med doi: 10.1084/jem.20051696 contributor: fullname: Vollmer – volume: 69 start-page: 20 year: 2010 ident: 2020061904534695300_dkaa114-B6 article-title: Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review publication-title: Ann Rheum Dis doi: 10.1136/ard.2008.101766 contributor: fullname: Ruiz-Irastorza – volume: 194 start-page: 4089 year: 2015 ident: 2020061904534695300_dkaa114-B14 article-title: Cutting edge: antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction publication-title: J Immunol doi: 10.4049/jimmunol.1402793 contributor: fullname: An – volume: 44 start-page: 398 year: 2017 ident: 2020061904534695300_dkaa114-B20 article-title: Increased incidence of gastrointestinal side effects in patients taking hydroxychloroquine: a brand-related issue? publication-title: J Rheumatol doi: 10.3899/jrheum.161063 contributor: fullname: Srinivasa – volume: 14 start-page: 693 year: 2018 ident: 2020061904534695300_dkaa114-B21 article-title: Hydroxychloroquine retinopathy—implications of research advances for rheumatology care publication-title: Nat Rev Rheumatol doi: 10.1038/s41584-018-0111-8 contributor: fullname: Jorge – volume: 126 start-page: 76 year: 2012 ident: 2020061904534695300_dkaa114-B22 article-title: Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.111.089268 contributor: fullname: Izmirly – start-page: 357 year: 1999 ident: 2020061904534695300_dkaa114-B24 article-title: Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension publication-title: Arthritis Rheum doi: 10.1002/1529-0131(199902)42:2<357::AID-ANR19>3.0.CO;2-J contributor: fullname: Furst – volume: 9 year: 2017 ident: 2020061904534695300_dkaa114-B5 article-title: Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aal3653 contributor: fullname: Sheahan – volume: 19 start-page: 183 year: 2017 ident: 2020061904534695300_dkaa114-B8 article-title: Hydroxychloroquine inhibits CD154 expression in CD4(+) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling publication-title: Arthritis Res Ther doi: 10.1186/s13075-017-1393-y contributor: fullname: Wu – volume: 5 start-page: e00293 year: 2017 ident: 2020061904534695300_dkaa114-B18 article-title: Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases publication-title: Pharmacol Res Perspect doi: 10.1002/prp2.293 contributor: fullname: Al-Bari – volume: 17 start-page: 6230 year: 1998 ident: 2020061904534695300_dkaa114-B12 article-title: CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation publication-title: EMBO J doi: 10.1093/emboj/17.21.6230 contributor: fullname: Hacker – volume: 202 start-page: 120 year: 2015 ident: 2020061904534695300_dkaa114-B16 article-title: Host cell proteases: critical determinants of coronavirus tropism and pathogenesis publication-title: Virus Res doi: 10.1016/j.virusres.2014.11.021 contributor: fullname: Millet – volume: 63 start-page: 457 year: 2020 ident: 2020061904534695300_dkaa114-B1 article-title: Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission publication-title: Sci China Life Sci doi: 10.1007/s11427-020-1637-5 contributor: fullname: Xu – volume: 348 start-page: 600 year: 1990 ident: 2020061904534695300_dkaa114-B7 article-title: Intracellular transport of class II MHC molecules directed by invariant chain publication-title: Nature doi: 10.1038/348600a0 contributor: fullname: Lotteau – volume: 16 start-page: 155 year: 2020 ident: 2020061904534695300_dkaa114-B17 article-title: Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology publication-title: Nat Rev Rheumatol doi: 10.1038/s41584-020-0372-x contributor: fullname: Schrezenmeier |
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A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide.... A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. The... |
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| SubjectTerms | Betacoronavirus Coronavirus Infections - drug therapy COVID-19 Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - prevention & control Disease Progression Humans Hydroxychloroquine - adverse effects Hydroxychloroquine - therapeutic use Leading Lymphocyte Activation - drug effects Pandemics Pneumonia, Viral - drug therapy Respiratory Distress Syndrome - drug therapy Respiratory Distress Syndrome - prevention & control Respiratory Distress Syndrome - virology SARS-CoV-2 T-Lymphocytes - drug effects |
| Title | COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression |
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