Persistence of Circulating Memory B Cell Clones with Potential for Dengue Virus Disease Enhancement for Decades following Infection

Symptomatic dengue virus infection ranges in disease severity from an influenza-like illness to life-threatening shock. One model of the mechanism underlying severe disease proposes that weakly neutralizing, dengue serotype cross-reactive antibodies induced during a primary infection facilitate viru...

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Bibliographic Details
Published in:	Journal of Virology Vol. 86; no. 5; pp. 2665 - 2675
Main Authors:	Smith, Scott A, Zhou, Yang, Olivarez, Nicholas P, Broadwater, Anne H, de Silva, Aravinda M, Crowe, James E. Jr
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-03-2012
Subjects:	Animals Antibodies, Blocking - immunology Antibodies, Viral - immunology B-lymphocytes B-Lymphocytes - immunology B-Lymphocytes - virology Biological and medical sciences Coinfection - immunology Coinfection - virology cross reaction Cross Reactions dengue Dengue - immunology Dengue - virology Dengue virus Dengue Virus - immunology Fundamental and applied biological sciences. Psychology Humans humoral immunity hybridomas Mice Microbiology Miscellaneous monoclonal antibodies neutralization neutralizing antibodies Pathogenesis and Immunity proteins serotypes vaccines Viral Envelope Proteins - immunology Virology viruses Virus B-Lymphocyte Flaviviridae Dengue virus Flavivirus Dengue group virus
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