Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone

• Published in: Brain, behavior, and immunity Vol. 64; pp. 320 - 329
• Main Authors: Cippitelli, Andrea, Domi, Esi, Ubaldi, Massimo, Douglas, James C, Li, Hong Wu, Demopulos, Gregory, Gaitanaris, George, Roberto, Marisa, Drew, Paul D, Kane, Cynthia J.M, Ciccocioppo, Roberto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-08-2017
• Subjects: Alcohol; Allergy and Immunology; Animals; Behavior, Animal - drug effects; Blood Alcohol Content; Cognitive flexibility; Cytokines; Cytokines - metabolism; Ethanol - administration & dosage; Ethanol - toxicity; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Male; Motor Activity - drug effects; Neurodegeneration; Neurons - drug effects; Neurons - pathology; Neuroprotective Agents - administration & dosage; Pioglitazone; PPAR gamma - agonists; PPARγ; Psychiatry; Rats, Wistar; Spatial Learning - drug effects; Spatial Memory - drug effects; Thiazolidinediones - administration & dosage; Alcohol; Cognitive flexibility; Cytokines; Neurodegeneration; Pioglitazone; PPARγ
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2017.02.001

Highlights • The PPARγ agonist pioglitazone reduces alcohol-induced neurodegeneration. • Pioglitazone prevents alcohol-induced expression of pro-inflammatory cytokines. • Pioglitazone prevents alcohol-impaired reversal learning ability in an operant task. • Pioglitazone improves reference memory in the Morris water maze task. • Pioglitazone prevents alcohol-induced deficits in spatial learning.