Prognostic factors in stage IB gastric cancer

Prognostic factors in stage IB gastric cancer

AIM:To identify the subset of patients with stage IB gastric cancer with an unfavorable prognosis.METHODS:Overall survival(OS)rates were examined in 103 patients with stage IB(T1N1M0 and T2N0M0)gastric cancer between January 2000 and December2011.Univariate and multivariate analyses were performed t...

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Published in:World journal of gastroenterology : WJG Vol. 20; no. 21; pp. 6580 - 6585
Main Authors: Aoyama, Toru, Yoshikawa, Takaki, Fujikawa, Hirohito, Hayashi, Tsutomu, Ogata, Takashi, Cho, Haruhiko, Yamada, Takanobu, Hasegawa, Shinichi, Tsuchida, Kazuhito, Yukawa, Norio, Oshima, Takashi, Oba, Mari S, Morita, Satoshi, Rino, Yasushi, Masuda, Munetaka
Format: Journal Article
Language:English
Published: United States Baishideng Publishing Group Inc 07-06-2014
Subjects:
Adult
Aged
Aged, 80 and over
cancer
Disease-Free Survival
factor
Female
Gastric
Humans
Japan
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Prognosis
Prognostic
Proportional Hazards Models
Retrospective Studies
Retrospective Study
Risk Factors
Stage
Stomach Neoplasms - diagnosis
Stomach Neoplasms - mortality
Stomach Neoplasms - physiopathology
Treatment Outcome
Japan
Prognostic factor
Gastric cancer
Stage IB
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Summary:AIM:To identify the subset of patients with stage IB gastric cancer with an unfavorable prognosis.METHODS:Overall survival(OS)rates were examined in 103 patients with stage IB(T1N1M0 and T2N0M0)gastric cancer between January 2000 and December2011.Univariate and multivariate analyses were performed to identify risk factors using a Cox proportional hazards model.RESULTS:The OS rates of patients with T1N1 and T2N0 cancer were 89.2%and 94.1%at 5-years,re-spectively.Both univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic factor.The OS rate was 81.8%at5-years when the tumor was located in the upper third of the stomach and was 95.5%at 5-years when the tumor was located in the middle or lower third of the stomach(P=0.0093).CONCLUSION:These data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer.
Bibliography:Toru Aoyama;Takaki Yoshikawa;Hirohito Fujikawa;Tsutomu Hayashi;Takashi Ogata;Haruhiko Cho;Takanobu Yamada;Shinichi Hasegawa;Kazuhito Tsuchida;Norio Yukawa;Takashi Oshima;Mari S Oba;Satoshi Morita;Yasushi Rino;Munetaka Masuda;Department of Gastrointestinal Surgery, Kanagawa Cancer Center,Yokohama 241-0815,Japan;Department of Surgery,Yokohama City University,Yokohama 236-0004,Japan;Department of Biostatistics and Epidemiology,Yokohama City University,Yokohama 236-0004,Japan
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SourceType-Scholarly Journals-1
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Telephone: +81-45-3915761 Fax: +81-45-3614692
Correspondence to: Dr. Takaki Yoshikawa, Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama 241-0815, Japan. yoshikawat@kcch.jp
Author contributions: Aoyama T and Yoshikawa T designed the research; Aoyama T, Yoshikawa T, Fujikawa H, Hayashi T, Ogata T, Cho H, Yamada T, Hasegawa S, Tsuchida K, Yukawa N, Oshima T, Rino Y and Masuda M performed the research; Oba MS and Morita S contributed new reagents/analytic tools; Oba MS and Morita S analyzed the data; and Aoyama T and Yoshikawa T wrote the paper.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i21.6580