New modular delivery system for diagnostic and therapeutic pre‐targeting using tautomer‐specific monoclonal antibody EM‐6‐47 and 3‐substituted adenines

We have developed a new modular affinity system for the 2‐step delivery of functional molecules to target cells. The system is based on the tautomer‐specific monoclonal antibody (MAb) EM‐6–47, which binds to 3‐ and 3,8‐substituted adenines with high affinity (Ka > 109 l/mol) without cross‐reactin...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of cancer Vol. 77; no. 4; pp. 610 - 619
Main Authors:	Krüger, Kai, Jochum, Christoph, Glüsenkamp, Karl‐Heinz, Krüsemann, Christa, Lorenz, Petra, Eberle‐Adamkiewicz, Gertrud, Drosdziok, Wolfgang, Beelen, Dietrich W., Coenen, Heinz H., Rajewsky, Manfred F.
Format:	Journal Article
Language:	English
Published:	New York Wiley Subscription Services, Inc., A Wiley Company 12-08-1998 Wiley-Liss
Subjects:	Adenine - chemistry Animals Antibodies, Bispecific - therapeutic use Antibodies, Monoclonal - therapeutic use Antineoplastic agents Biological and medical sciences Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Dogs Drug Delivery Systems Haptens - metabolism Immunotoxins - administration & dosage Indium Radioisotopes - therapeutic use Medical sciences Pharmacology. Drug treatments Adenine derivatives Human Delivery system Target Treatment Immunoradiotherapy Monoclonal antibody Diagnosis Tautomer Radiotherapy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!