HI responses induced by seasonal influenza vaccination are associated with clinical protection and with seroprotection against non-homologous strains

• Published in: Vaccine Vol. 30; no. 35; pp. 5262 - 5269
• Main Authors: Luytjes, Willem, Enouf, Vincent, Schipper, Maarten, Gijzen, Karlijn, Liu, Wai Ming, van der Lubben, Mariken, Meijer, Adam, van der Werf, Sylvie, Soethout, Ernst C
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 27-07-2012; Elsevier Limited
• Subjects: Adolescent; Adult; Age; Allergy and Immunology; Antibodies, Viral - blood; Binding sites; Clinical study; Cohort Studies; Cross Protection; Cross-specific immunity; Female; Follow-Up Studies; hemagglutination; Hemagglutination inhibition; Hemagglutination Inhibition Tests; Hemophilia; Humans; Immunity, Humoral; Infections; Influenza; Influenza A virus; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H1N1 Subtype - isolation & purification; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Influenza virus; Influenza, Human - immunology; Influenza, Human - prevention & control; Logistic Models; Male; Middle Aged; Older people; pandemic; Pandemics; Studies; Swine flu; Vaccination; Vaccines; Young Adult; young adults; Cross-specific immunity; Hemagglutination inhibition; Influenza; Vaccination; Clinical study
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.05.060

Highlights ► We examine homologous and cross-specific HI responses after influenza vaccination in 2006/2007. ► Homologous HI titers before and after vaccination correlate with laboratory confirmed influenza. ► Vaccination will induce cross-specific HI titers ≥40 against H1N1pdm09 and drifted seasonal H1N1. ► We find no indications that original antigenic sin may affect cross-specific HI titers. ► Between 20 and 60 years, cross-specific HI titers ≥40 against H1N1pdm09 are inversely correlated with age.