In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L
Tanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T. balsamita as a pain killer and relief of inflammatory based disorders in Iranian folk medicine and considering the high content of essential oil in T. b...
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| Abstract | Tanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T. balsamita as a pain killer and relief of inflammatory based disorders in Iranian folk medicine and considering the high content of essential oil in T. balsamita aerial parts, we were prompted to investigate the anti-nociceptive and anti-inflammatory properties of T. balsamita essential oil (TBEO) for the first time. The carrageenan-induced Paw Edema was used for inflammation evaluation in rat, and hot-plate method was used for pain assessment in mice. Different doses of TBEO were administered. Morphine and Mefenamic acid were used as the standard drugs in anti-nociceptive and anti-inflammatory evaluation tests, respectively. TBEO (100 mg/kg) showed significantly anti-nociceptive activity in hot-plate test. The anti-inflammatory activity of TBEO was found to be more than mefenamic acid. The studied oil was analyzed by GC and GC-MS. The major component of the oil was characterized as carvone (39.8%) which might be responsible for the observed activities. The results suggested that TBEO possessed biologically active constituents that had significant analgesic and anti-inflammatory effects which support the ethno-medicinal claims of the plant application in the management of pain and inflammation. |
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| AbstractList | Tanacetum balsamita locally called Shahesparam is an aromatic plant that grows widely in Azerbaijan Province, Iran. Due to the widespread use of T. balsamita as a pain killer and relief of inflammatory based disorders in Iranian folk medicine and considering the high content of essential oil in T. balsamita aerial parts, we were prompted to investigate the anti-nociceptive and anti-inflammatory properties of T. balsamita essential oil (TBEO) for the first time. The carrageenan-induced Paw Edema was used for inflammation evaluation in rat, and hot-plate method was used for pain assessment in mice. Different doses of TBEO were administered. Morphine and Mefenamic acid were used as the standard drugs in anti-nociceptive and anti-inflammatory evaluation tests, respectively. TBEO (100 mg/kg) showed significantly anti-nociceptive activity in hot-plate test. The anti-inflammatory activity of TBEO was found to be more than mefenamic acid. The studied oil was analyzed by GC and GC-MS. The major component of the oil was characterized as carvone (39.8%) which might be responsible for the observed activities. The results suggested that TBEO possessed biologically active constituents that had significant analgesic and anti-inflammatory effects which support the ethno-medicinal claims of the plant application in the management of pain and inflammation. |
| Author | Najafizadeh, Parvaneh Mousavi, Zahra Sharif, Maryam Asgarpanah, Jinous |
| AuthorAffiliation | Iran University of Medical Sciences Islamic Azad University |
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| Cites_doi | 10.1515/znc-2007-1-207 10.1111/j.2042-7158.1987.tb03421.x 10.1136/bmj.291.6495.569 10.1248/bpb.29.811 10.1248/bpb.31.1017 10.1007/s11418-012-0738-8 10.1016/S0378-8741(03)00118-1 10.3181/00379727-111-27849 10.1016/j.fitote.2012.10.012 |
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| References | Johnson ES (ref6) 1985; 291 Marques TH (ref8) 2014; 37 Nickavar B (ref11) 2010; 2 Swigar AA (ref15) 1981 Gonçalves JCR (ref4) 2008; 31 da Rocha ML (ref2) 2013; 67 Hayes N (ref5) 1987; 39 de Sousa DP (ref13) 2007; 62 Winter CA (ref16) 1962; 111 de Sousa DP (ref3) 2006; 29 Yousefzadi M (ref17) 2009; 4 Mozaffarian V (ref10) 2006 Adams RP (ref1) 1995 Lotfipour F (ref7) 2008; 11 Petrovic SD (ref12) 2003; 87 McDonald AD (ref9) 1946; 1 Souza FV (ref14) 2013; 85 Nickavar, B; Amin, G; Mehregan, N 2010; 2 de Sousa, DP; Junior, EV; Oliviera, FS; de Almeida, RN; Nunes, XP; Barbosa-Filho, JM 2007; 62 McDonald, AD; Woolfe, G; Bergel, F; Morrison, AL; Rinderknecht, H 1946; 1 Gonçalves, JCR; de Sousa Oliveira, F; Benedito, RB; de Sousa, DP; de Almeida, RN; de Araujo, DA 2008; 31 Lotfipour, F; Nazemiyeh, H; Fathi-Azad, F; garaei, N; Arami, S; Talat, S; Sadegpour, F; Hasanpour, R 2008; 11 Hayes, N; Foreman, J 1987; 39 da Rocha, ML; Oliveira, LE; Patricio Santos, CC; de Sousa, DP; de Almeida, RN; Araujo, DA 2013; 67 de Sousa, DP; de Sousa Oliveira, F; de Almeida, RN 2006; 29 Marques, TH; Marques, ML; Medeiros, JV; Silva, RO; dos Reis Barbosa, AL; Lima, TC; de Sousa, DP; de Freitas, RM 2014; 37 Johnson, ES; Kadam, NP; Hylands, DM; hylands, PJ 1985; 291 Souza, FV; da Rocha, MB; de Souza, DP; Marcal, RM 2013; 85 Mozaffarian, V 2006 Winter, CA; Risley, EA; Nuss, GW 1962; 111 Adams, RP 1995 Petrovic, SD; Dobric, S; Bokonjic, D; Niketic, M; Garcia-Pineres, A; Merfort, I 2003; 87 Swigar, AA; Silverstein, RM 1981 Yousefzadi, M; Ebrahimi, SN; Sonboli, A; Miraghasi, F; Ghiasi, S; Arman, M; Mosaffa, N 2009; 4 |
| References_xml | – volume: 62 start-page: 39 issue: 1-2 year: 2007 ident: ref13 article-title: Anti-nociceptive activity of structural analogues of Rotundifolone: structure-activity relationship publication-title: Z Naturforsch C doi: 10.1515/znc-2007-1-207 contributor: fullname: de Sousa DP – volume: 11 start-page: 80 issue: 2 year: 2008 ident: ref7 article-title: Evaluation of antibacterial activities of some medicinal plants from North-West Iran publication-title: Iran J Basic Med Sci contributor: fullname: Lotfipour F – year: 1981 ident: ref15 contributor: fullname: Swigar AA – volume: 4 start-page: 119 issue: 1 year: 2009 ident: ref17 article-title: Cytotoxicity, antimicrobial activity and composition of essential oil from Tanacetum balsamita L. subsp. balsamita publication-title: Nat Prod Commun contributor: fullname: Yousefzadi M – volume: 39 start-page: 466 issue: 6 year: 1987 ident: ref5 article-title: The activity of compounds extracted from feverfew on histamine release from rat mast cells publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1987.tb03421.x contributor: fullname: Hayes N – volume: 291 start-page: 569 issue: 6495 year: 1985 ident: ref6 article-title: Efficacy of feverfew as prophylactic treatment of migraine publication-title: Br Med J doi: 10.1136/bmj.291.6495.569 contributor: fullname: Johnson ES – volume: 29 start-page: 811 issue: 4 year: 2006 ident: ref3 article-title: Evaluation of the central activity of hydroxydihydrocarvone publication-title: Biol Pharm Bull doi: 10.1248/bpb.29.811 contributor: fullname: de Sousa DP – volume: 31 start-page: 1017 issue: 5 year: 2008 ident: ref4 article-title: Anti-nociceptive activity of (−)-Carvone: evidence of association with decreased peripheral nerve excitability publication-title: Biol Pharm Bull doi: 10.1248/bpb.31.1017 contributor: fullname: Gonçalves JCR – volume: 67 start-page: 743 issue: 4 year: 2013 ident: ref2 article-title: Anti-nociceptive and anti-inflammatory effects of the monoterpene α, β-epoxy-Carvone in mice publication-title: J Nat Med doi: 10.1007/s11418-012-0738-8 contributor: fullname: da Rocha ML – volume: 37 start-page: 966 issue: 3 year: 2014 ident: ref8 article-title: Cyane-Carvone, a synthetic derivative of carvone, inhibits inflammatory response by reducing cytokine production and oxidative stress and shows anti-nociceptive effect in mice publication-title: Inflammation contributor: fullname: Marques TH – volume: 87 start-page: 109 issue: 1 year: 2003 ident: ref12 article-title: Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats publication-title: J Ethnopharmacol doi: 10.1016/S0378-8741(03)00118-1 contributor: fullname: Petrovic SD – volume: 2 start-page: 249 issue: 4 year: 2010 ident: ref11 article-title: Quercetine, a major flavonol aglycon from Tanacetum balsamita L. publication-title: Iran J Pharm Res contributor: fullname: Nickavar B – year: 1995 ident: ref1 contributor: fullname: Adams RP – volume: 1 start-page: 4 issue: 1 year: 1946 ident: ref9 article-title: Analgesic action of pethidine derivatives and related compounds publication-title: Brit J Pharmacol contributor: fullname: McDonald AD – volume: 111 start-page: 544 issue: 3 year: 1962 ident: ref16 article-title: Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs publication-title: Exp Biol Med doi: 10.3181/00379727-111-27849 contributor: fullname: Winter CA – year: 2006 ident: ref10 contributor: fullname: Mozaffarian V – volume: 85 start-page: 20 year: 2013 ident: ref14 article-title: (−)-Carvone: Antispasmodic effect and mode of action publication-title: Fitoterapia doi: 10.1016/j.fitote.2012.10.012 contributor: fullname: Souza FV – year: 1995 publication-title: Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy contributor: fullname: Adams, RP – volume: 62 start-page: 39 issue: 1-2 year: 2007 end-page: 42 article-title: Anti-nociceptive activity of structural analogues of Rotundifolone: structure-activity relationship publication-title: Z Naturforsch C contributor: fullname: de Sousa, DP; Junior, EV; Oliviera, FS; de Almeida, RN; Nunes, XP; Barbosa-Filho, JM – volume: 39 start-page: 466 issue: 6 year: 1987 end-page: 470 article-title: The activity of compounds extracted from feverfew on histamine release from rat mast cells publication-title: J Pharm Pharmacol contributor: fullname: Hayes, N; Foreman, J – volume: 31 start-page: 1017 issue: 5 year: 2008 end-page: 1020 article-title: Anti-nociceptive activity of (−)-Carvone: evidence of association with decreased peripheral nerve excitability publication-title: Biol Pharm Bull contributor: fullname: Gonçalves, JCR; de Sousa Oliveira, F; Benedito, RB; de Sousa, DP; de Almeida, RN; de Araujo, DA – year: 2006 publication-title: A Dictionary of Iranian Plant Names contributor: fullname: Mozaffarian, V – year: 1981 publication-title: Monoterpenes contributor: fullname: Swigar, AA; Silverstein, RM – volume: 67 start-page: 743 issue: 4 year: 2013 end-page: 749 article-title: Anti-nociceptive and anti-inflammatory effects of the monoterpene α, β-epoxy-Carvone in mice publication-title: J Nat Med contributor: fullname: da Rocha, ML; Oliveira, LE; Patricio Santos, CC; de Sousa, DP; de Almeida, RN; Araujo, DA – volume: 29 start-page: 811 issue: 4 year: 2006 end-page: 812 article-title: Evaluation of the central activity of hydroxydihydrocarvone publication-title: Biol Pharm Bull contributor: fullname: de Sousa, DP; de Sousa Oliveira, F; de Almeida, RN – volume: 291 start-page: 569 issue: 6495 year: 1985 end-page: 573 article-title: Efficacy of feverfew as prophylactic treatment of migraine publication-title: Br Med J contributor: fullname: Johnson, ES; Kadam, NP; Hylands, DM; hylands, PJ – volume: 87 start-page: 109 issue: 1 year: 2003 end-page: 113 article-title: Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats publication-title: J Ethnopharmacol contributor: fullname: Petrovic, SD; Dobric, S; Bokonjic, D; Niketic, M; Garcia-Pineres, A; Merfort, I – volume: 1 start-page: 4 issue: 1 year: 1946 end-page: 14 article-title: Analgesic action of pethidine derivatives and related compounds publication-title: Brit J Pharmacol contributor: fullname: McDonald, AD; Woolfe, G; Bergel, F; Morrison, AL; Rinderknecht, H – volume: 85 start-page: 20 year: 2013 end-page: 24 article-title: (−)-Carvone: Antispasmodic effect and mode of action publication-title: Fitoterapia contributor: fullname: Souza, FV; da Rocha, MB; de Souza, DP; Marcal, RM – volume: 111 start-page: 544 issue: 3 year: 1962 end-page: 547 article-title: Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs publication-title: Exp Biol Med contributor: fullname: Winter, CA; Risley, EA; Nuss, GW – volume: 2 start-page: 249 issue: 4 year: 2010 end-page: 250 article-title: Quercetine, a major flavonol aglycon from Tanacetum balsamita L. publication-title: Iran J Pharm Res contributor: fullname: Nickavar, B; Amin, G; Mehregan, N – volume: 11 start-page: 80 issue: 2 year: 2008 end-page: 85 article-title: Evaluation of antibacterial activities of some medicinal plants from North-West Iran publication-title: Iran J Basic Med Sci contributor: fullname: Lotfipour, F; Nazemiyeh, H; Fathi-Azad, F; garaei, N; Arami, S; Talat, S; Sadegpour, F; Hasanpour, R – volume: 37 start-page: 966 issue: 3 year: 2014 end-page: 977 article-title: Cyane-Carvone, a synthetic derivative of carvone, inhibits inflammatory response by reducing cytokine production and oxidative stress and shows anti-nociceptive effect in mice publication-title: Inflammation contributor: fullname: Marques, TH; Marques, ML; Medeiros, JV; Silva, RO; dos Reis Barbosa, AL; Lima, TC; de Sousa, DP; de Freitas, RM – volume: 4 start-page: 119 issue: 1 year: 2009 end-page: 122 article-title: Cytotoxicity, antimicrobial activity and composition of essential oil from Tanacetum balsamita L. subsp. balsamita publication-title: Nat Prod Commun contributor: fullname: Yousefzadi, M; Ebrahimi, SN; Sonboli, A; Miraghasi, F; Ghiasi, S; Arman, M; Mosaffa, N |
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| Title | In vivo analgesic and anti-inflammatory effects of the essential oil from Tanacetum balsamita L |
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