Evaluation of various silver-containing dressing on infected excision wound healing study

• Published in: Journal of materials science. Materials in medicine Vol. 25; no. 5; pp. 1375 - 1386
• Main Authors: Lin, Yu-Hsin, Hsu, Wei-Shan, Chung, Wan-Yu, Ko, Tse-Hao, Lin, Jui-Hsiang
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-05-2014; Springer; Springer Nature B.V
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - chemistry; Bacterial Infections - pathology; Bacterial Infections - therapy; Bandages; Biological and medical sciences; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Ceramics; Chemistry and Materials Science; Combined Modality Therapy; Composites; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - chemistry; Dose-Response Relationship, Drug; Glass; Materials Science; Materials Testing; Medical sciences; Metal Nanoparticles - administration & dosage; Metal Nanoparticles - chemistry; Natural Materials; Polymer Sciences; Rats; Rats, Sprague-Dawley; Regenerative Medicine/Tissue Engineering; Silver; Silver - administration & dosage; Silver - chemistry; Surfaces and Interfaces; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical Wound Infection - pathology; Surgical Wound Infection - therapy; Technology. Biomaterials. Equipments; Thin Films; Treatment Outcome; Wound healing; Wound Healing - drug effects; Silver Concentration; Silver Sulfadiazine; Silver Content; Wound Area; Activate Carbon Fiber; Infection; Silver; Dressing; Cicatrization; Wound; Biomedical engineering
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-014-5152-1

Silver-containing dressings have been widely used for controlling wound infection. However, the relationship between different concentrations of silver in dressings and their antimicrobial activities and wound-healing efficacies remains unclear. In the present study, we (in cooperation with Bio-medical Carbon Technology) investigated various silver-containing activated carbon fibers to understand the effects of different silver concentrations on the efficacies of a silver containing dressing. Our results indicated that various silver-containing activated carbon fibers exhibited good antibacterial effects and biocompatibility in terms of cell viability and that silver concentration showed a minor influence on cell growth. The infected excision wound model indicated that compared to silver-containing activated carbon fiber and other commercial silver-containing dressings assisted wound healing by promoting granulation and collagen deposition. Meanwhile, the silver ion can only be restrained in epidermis by intact skin. During application on the wound area, a temporary increase of serum silver can be detected, but this elevated serum silver level decreased to a subtle level after the removal of silver-containing activated carbon fiber.