Cancer stem cell self-renewal as a therapeutic target in human oral cancer

Tumor recurrence following treatment remains a major clinical challenge in oral cavity cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been considered as the driving force of tumor recurrence and metastasis. However, it still remains unclear whether targeting CSCs in...

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Bibliographic Details
Published in:	Oncogene Vol. 38; no. 27; pp. 5440 - 5456
Main Authors:	Hu, Jinwei, Mirshahidi, Saied, Simental, Alfred, Lee, Steve C., De Andrade Filho, Pedro A., Peterson, Nathaniel R., Duerksen-Hughes, Penelope, Yuan, Xiangpeng
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-07-2019 Nature Publishing Group
Subjects:	13 13/100 13/106 13/31 13/95 631/67/71 631/80 64/60 82/80 96/63 Aldehyde Dehydrogenase - metabolism Apoptosis Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Care and treatment Cell Biology Cell death Cell Proliferation Cell Self Renewal Cisplatin Development and progression Diseases Heterografts Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Metastases Metastasis Mouth cancer Mouth Neoplasms - pathology Mouth Neoplasms - therapy Neoplastic Stem Cells - cytology Oncology Oral cancer Oral cavity Polycomb Repressive Complex 1 - antagonists & inhibitors Polycomb Repressive Complex 1 - metabolism Proof of Concept Study Relapse Risk factors Squamous cell carcinoma Stem cells Therapeutic applications Tumors Xenografts
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