Success Rates, Characteristics, and Costs of Articulating Antibiotic Spacers for Total Knee Periprosthetic Joint Infection

• Published in: The knee Vol. 24; no. 5; pp. 1175 - 1181
• Main Authors: Nodzo, Scott R, Boyle, Keely, Spiro, Sara, Nocon, Allina A, Miller, Andy O, Westrich, Geoffrey H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-10-2017; Elsevier Limited
• Subjects: Aged; Aminoglycoside antibiotics; Aminoglycosides - administration & dosage; Anti-Bacterial Agents - administration & dosage; Antibiotic spacer; Antibiotics; Arthroplasty (knee); Arthroplasty, Replacement, Knee - adverse effects; Articulating knee spacer; Bone Cements; Cement; Complications; Demography; Disease control; Female; Femur; Humans; Infections; Infectious diseases; Joint diseases; Joint surgery; Knee; Knee Prosthesis - economics; Laboratories; Male; Middle Aged; Orthopedics; Outcomes; Patients; Periprosthetic joint infection; Polymethyl Methacrylate; Prosthesis-Related Infections - economics; Prosthesis-Related Infections - etiology; Prosthesis-Related Infections - microbiology; Prosthesis-Related Infections - surgery; Reoperation - economics; Retrospective Studies; Statistical analysis; Success; Surgeons; Vancomycin; Vancomycin - administration & dosage; Articulating knee spacer; Periprosthetic joint infection; Complications; Outcomes; Antibiotic spacer
• DOI: 10.1016/j.knee.2017.05.016
• EISSN: 1873-5800
• ISSN: 0968-0160

Abstract Introduction The optimal type, characteristics, and success rates of articulating antibiotic spacers used during total knee arthroplasty (TKA) periprosthetic joint infection (PJI) have not been well defined in a single series. We sought to 1) determine the success rate for three unique spacer constructs and (2) evaluate any microbiological, surgical, or patient characteristics that would influence the success rate. Methods We retrospectively reviewed patients who underwent a two-stage exchange for a TKA PJI with a prefabricated spacer (PREFAB), home-made mold (MOLD), or autoclaved femoral component (AUTOCL). Patient demographics, microbiology data, amount of antibiotic in each spacer construct, postoperative course, and infection cure outcomes were evaluated. Results The success rate for being infection free at final follow up without the need for further reoperation for infection was 82.7% in the PREFAB group, 88.4% in the MOLD group, and 79.4% in the AUTOCL group (p = 0.54). There was no clear statistical link between raw quantities of vancomycin and aminoglycoside in the spacer and a successful outcome. The surgeon's own intraoperatively created mold group had the lowest construct cost at a mean $1341.00 ± 889.10 (p < 0.0001) per construct, while the commercial cement molds had the highest mean cost at $5439.00 ± 657.80(p < 0.0001). Discussion There was no statistically significant difference in the success rates between the antibiotic spacer types. The surgeon's own intraoperative mold had the least overall associated cost.