Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model

Rationale ( R,S )-ketamine, an N -methyl-D-aspartate receptor (NMDAR) antagonist, exhibits rapid and long-lasting antidepressant effects and anti-suicidal ideation in treatment-resistant patients with depression. However, the precise mechanisms underlying the antidepressant actions of ( R,S )-ketami...

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Bibliographic Details
Published in:	Psychopharmacology Vol. 235; no. 11; pp. 3177 - 3185
Main Authors:	Zhang, Kai, Toki, Hidetoh, Fujita, Yuko, Ma, Min, Chang, Lijia, Qu, Youge, Harada, Shingo, Nemoto, Tetsuhiro, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-ichi, Chaki, Shigeyuki, Hashimoto, Kenji
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2018 Springer Springer Nature B.V
Subjects:	Analysis Animals Antidepressants Antidepressive Agents - administration & dosage Antidepressive Agents - chemistry Antidepressive Agents - metabolism Antidepressive Agents - pharmacology Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Care and treatment Chronic Disease Depression (Mood disorder) Depression - drug therapy Depression - metabolism Depression - psychology Deuterium Deuterium - administration & dosage Deuterium - chemistry Deuterium - metabolism Disease Models, Animal Dosage and administration Glutamic acid receptors Isotope effect Isotopes Ketamine Ketamine - administration & dosage Ketamine - analogs & derivatives Ketamine - chemistry Ketamine - metabolism Male Mental depression Metabolism Mice Mice, Inbred C57BL N-Methyl-D-aspartic acid receptors Neurosciences Original Investigation Pharmacology/Toxicology Psychiatry Social interactions Stress, Psychological - drug therapy Stress, Psychological - metabolism Stress, Psychological - psychology Treatment Outcome 2 Deuterium isotope effect ketamine 6 ( hydroxynorketamine Metabolism (2R,6R)-hydroxynorketamine (R)-ketamine
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