Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase

The aminoacyl-tRNA synthetases link tRNAs with their cognate amino acid. In some cases, their fidelity relies on hydrolytic editing that destroys incorrectly activated amino acids or mischarged tRNAs. We present structures of leucyl-tRNA synthetase complexed with analogs of the distinct pre- and pos...

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Bibliographic Details
Published in:	Molecular cell Vol. 11; no. 4; pp. 951 - 963
Main Authors:	Lincecum, Tommie L., Tukalo, Michael, Yaremchuk, Anna, Mursinna, Richard S., Williams, Amy M., Sproat, Brian S., Van Den Eynde, Wendy, Link, Andreas, Van Calenbergh, Serge, Grøtli, Morten, Martinis, Susan A., Cusack, Stephen
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-04-2003
Subjects:	Adenosine - analogs & derivatives Adenosine - metabolism Amino Acids - genetics Amino Acids - metabolism Aspartic Acid - genetics Aspartic Acid - metabolism Binding Sites - genetics Leucine-tRNA Ligase - genetics Leucine-tRNA Ligase - metabolism Macromolecular Substances Molecular Conformation Protein Biosynthesis - genetics Proteins - genetics RNA Editing - genetics RNA, Transfer - genetics RNA, Transfer - metabolism
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