Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes

Sortilin is a multiligand sorting receptor responsible for the anterograde transport of lysosomal enzymes and substrates. Here we demonstrate that sortilin is also involved in retrograde protein traffic. In cultured 3T3-L1 adipocytes, sortilin together with retromer rescues Glut4 from degradation in...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular biology of the cell Vol. 28; no. 12; pp. 1667 - 1675
Main Authors:	Pan, Xiang, Zaarur, Nava, Singh, Maneet, Morin, Peter, Kandror, Konstantin V
Format:	Journal Article
Language:	English
Published:	United States The American Society for Cell Biology 15-06-2017
Series:	A Highlights from
Subjects:	3T3-L1 Cells Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Adipocytes - metabolism Animals Biological Transport Cell Membrane - metabolism Endosomes - metabolism Glucose Transporter Type 4 - metabolism Insulin - metabolism Insulin Resistance Lysosomes Mice Muscle Proteins - metabolism Protein Domains Protein Transport - physiology Sorting Nexins - metabolism trans-Golgi Network - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!