Alpha-Synuclein and Chaperones in Dementia With Lewy Bodies

The protein alpha-synuclein (ASYN) is thought to be involved in the development of dementia with Lewy bodies (DLB). Overexpression of ASYN has been linked to cellular toxicity and human disease, and in experimental models, chaperones such as heat shock proteins (HSPs) are protective against ASYN tox...

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Bibliographic Details
Published in:	Journal of neuropathology and experimental neurology Vol. 64; no. 12; pp. 1058 - 1066
Main Authors:	Cantuti-Castelvetri, Ippolita, Klucken, Jochen, Ingelsson, Martin, Ramasamy, Karunya, McLean, Pamela J, Frosch, Matthew P, Hyman, Bradley T, Standaert, David G
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD American Association of Neuropathologists, Inc 01-12-2005 Lippincott Williams & Wilkins Oxford University Press
Subjects:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Biological and medical sciences Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Detergents HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Lewy Body Disease - metabolism Medical sciences Molecular Chaperones - genetics Molecular Chaperones - metabolism Neurology Neurosurgery Octoxynol Polymerase Chain Reaction RNA, Messenger - metabolism Skull, brain, vascular surgery Solubility Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Temporal Lobe - metabolism Polymerase chain reaction Nervous system diseases Real-time PCR Chaperone Central nervous system Lewy body dementia Temporal cortex Alpha-synuclein Molecular chaperone Encephalon Dementia with Lewy bodies
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