Cellular origins of human polymeric and monomeric IgA: enumeration of single cells secreting polymeric IgA1 and IgA2 in peripheral blood, bone marrow, spleen, gingiva and synovial tissue

SUMMARY Using modified ELISA and spot‐ELISA, which permit the parallel determination of heavy chain subclass and the presence of covalently linked J chain, we analysed IgA found in cell culture supernatants or secreted by individual cells from peripheral blood, spleen, bone marrow, gingiva and synov...

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Bibliographic Details
Published in:	Clinical and experimental immunology Vol. 85; no. 2; pp. 341 - 348
Main Authors:	TARKOWSKI, A., MOLDOVEANU, Z., KOOPMAN, W. J., RADL, J., HAAIJMAN, J. J., MESTECKY, J.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-08-1991 Blackwell
Subjects:	Adult Antibodies, immunoglobulins Biological and medical sciences Bone Marrow - immunology Bone Marrow - metabolism Bone Marrow Cells Fundamental and applied biological sciences. Psychology Fundamental immunology Gingiva - cytology Gingiva - immunology Gingiva - metabolism Humans IgA1 IgA2 IgA‐secreting cells Immunoglobulin A - metabolism Immunoglobulin J-Chains - analysis Lymphocytes - metabolism Molecular immunology monomeric IgA Pokeweed Mitogens - pharmacology polymeric IgA Spleen - cytology Spleen - immunology Spleen - metabolism Structure Synovial Membrane - cytology Synovial Membrane - immunology Synovial Membrane - metabolism Human Spleen Molecular form IgA Immunoglobulins Cell supernatant Secretion Secretory cell Isotype Polymer Synovial membrane Bone marrow Gingiva Monomer Cell origin
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