MAPKAP kinase 2–mediated phosphorylation of HspA1L protects male germ cells from heat stress–induced apoptosis

Developing male germ cells are extremely sensitive to heat stress; consequently, anatomic and physiologic adaptations have evolved to maintain proper thermorégulation during mammalian spermatogenesis. At the cellular level, increased expression and activity of HSP70 family members occur in response...

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Bibliographic Details
Published in:	Cell stress & chaperones Vol. 24; no. 6; pp. 1127 - 1136
Main Authors:	Williams, Patrick A., Kobilnyk, Heather E., McMillan, Emily A., Strochlic, Todd I.
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer 01-11-2019 Springer Netherlands Springer Nature B.V
Subjects:	Adaptation Animals Apoptosis Apoptosis - physiology Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Cell Line Germ cells Heat stress Heat tolerance Heat-Shock Response - physiology HSP70 Heat-Shock Proteins - physiology Hsp70 protein Hyperthermia Immunology Intracellular Signaling Peptides and Proteins - metabolism Kinases Male MAP kinase MAPKAP kinase MAPKAP kinase 2 Neurosciences Nucleotides Original Paper Phosphorylation Protein Serine-Threonine Kinases - metabolism Proteomics Recovery of function Signal transduction Signaling Spermatogenesis Spermatogenesis - physiology Spermatozoa - cytology Spermatozoa - metabolism Substrates Testes Thermoregulation HspA1L MAPKAP kinase 2 Stress signaling MK2 Spermatogenesis Heat shock protein
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