Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?

Prion diseases are disorders that share several characteristics that are typical of many neurodegenerative diseases. Recently, several studies have extended the prion concept to pathological aggregation in malignant tumors involving misfolded p53, a tumor-suppressor protein. The aggregation of p53 a...

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Bibliographic Details

Published in:	Cold Spring Harbor perspectives in biology Vol. 8; no. 10; p. a023614
Main Authors:	Costa, Danielly C F, de Oliveira, Guilherme A P, Cino, Elio A, Soares, Iaci N, Rangel, Luciana P, Silva, Jerson L
Format:	Journal Article
Language:	English
Published:	United States Cold Spring Harbor Laboratory Press 01-10-2016
Subjects:	Genes, p53 Humans Intrinsically Disordered Proteins - metabolism Neoplasms - genetics Neoplasms - metabolism PERSPECTIVES Prion Diseases - metabolism Prions - metabolism Protein Binding Protein Folding Tumor Suppressor Proteins - metabolism
Online Access:	Get full text
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