Low level anti-Hu reactivity: A risk marker for small cell lung cancer?
Abstract Background : Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a population-based design. Methods : We used s...
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| Published in: | Cancer detection and prevention Vol. 32; no. 4; pp. 292 - 299 |
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| Main Authors: | , , , , , , |
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01-01-2009
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| Abstract | Abstract Background : Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a population-based design. Methods : We used stored plasma specimens to evaluate anti-Hu reactivity in relationship to small cell lung cancer in a population-based case–control study. Using Western Blot analysis, we measured anti-Hu reactivity against recombinant Hu family member, HuD, in plasma samples from 41 SCLC cases and 79 controls individually matched for age, race, sex, and smoking status (never, past, current). We analyzed the association between anti-Hu reactivity and SCLC using conditional logistic regression. Results : Anti-Hu reactivity was associated with SCLC, both before and after adjustment for amount of smoking. We observed a smoking-adjusted odds ratio of 3.2 (95% confidence interval from 0.98 to 13.4) comparing subjects above 1800 units (the lower limit of the second tertile of the distribution among antibody positive controls) to subjects with lower reactivity. We also found suggestive evidence in follow-up of our cases that anti-Hu above 1800 units was related to longer-term survival from SCLC. The present research is the first report of anti-Hu reactivity and SCLC in a population-based study. Conclusions : Given the suggestive evidence in this study, prospective analyses to examine whether anti-Hu reactivity might predict risk of developing SCLC, or whether anti-Hu reactivity could serve as an early marker for SCLC, may be warranted. |
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| AbstractList | Abstract Background : Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a population-based design. Methods : We used stored plasma specimens to evaluate anti-Hu reactivity in relationship to small cell lung cancer in a population-based case–control study. Using Western Blot analysis, we measured anti-Hu reactivity against recombinant Hu family member, HuD, in plasma samples from 41 SCLC cases and 79 controls individually matched for age, race, sex, and smoking status (never, past, current). We analyzed the association between anti-Hu reactivity and SCLC using conditional logistic regression. Results : Anti-Hu reactivity was associated with SCLC, both before and after adjustment for amount of smoking. We observed a smoking-adjusted odds ratio of 3.2 (95% confidence interval from 0.98 to 13.4) comparing subjects above 1800 units (the lower limit of the second tertile of the distribution among antibody positive controls) to subjects with lower reactivity. We also found suggestive evidence in follow-up of our cases that anti-Hu above 1800 units was related to longer-term survival from SCLC. The present research is the first report of anti-Hu reactivity and SCLC in a population-based study. Conclusions : Given the suggestive evidence in this study, prospective analyses to examine whether anti-Hu reactivity might predict risk of developing SCLC, or whether anti-Hu reactivity could serve as an early marker for SCLC, may be warranted. Background: Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a population-based design. Methods: We used stored plasma specimens to evaluate anti-Hu reactivity in relationship to small cell lung cancer in a population-based case–control study. Using Western Blot analysis, we measured anti-Hu reactivity against recombinant Hu family member, HuD, in plasma samples from 41 SCLC cases and 79 controls individually matched for age, race, sex, and smoking status (never, past, current). We analyzed the association between anti-Hu reactivity and SCLC using conditional logistic regression. Results: Anti-Hu reactivity was associated with SCLC, both before and after adjustment for amount of smoking. We observed a smoking-adjusted odds ratio of 3.2 (95% confidence interval from 0.98 to 13.4) comparing subjects above 1800 units (the lower limit of the second tertile of the distribution among antibody positive controls) to subjects with lower reactivity. We also found suggestive evidence in follow-up of our cases that anti-Hu above 1800 units was related to longer-term survival from SCLC. The present research is the first report of anti-Hu reactivity and SCLC in a population-based study. Conclusions: Given the suggestive evidence in this study, prospective analyses to examine whether anti-Hu reactivity might predict risk of developing SCLC, or whether anti-Hu reactivity could serve as an early marker for SCLC, may be warranted. Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a population-based design. We used stored plasma specimens to evaluate anti-Hu reactivity in relationship to small cell lung cancer in a population-based case-control study. Using Western Blot analysis, we measured anti-Hu reactivity against recombinant Hu family member, HuD, in plasma samples from 41 SCLC cases and 79 controls individually matched for age, race, sex, and smoking status (never, past, current). We analyzed the association between anti-Hu reactivity and SCLC using conditional logistic regression. Anti-Hu reactivity was associated with SCLC, both before and after adjustment for amount of smoking. We observed a smoking-adjusted odds ratio of 3.2 (95% confidence interval from 0.98 to 13.4) comparing subjects above 1800 units (the lower limit of the second tertile of the distribution among antibody positive controls) to subjects with lower reactivity. We also found suggestive evidence in follow-up of our cases that anti-Hu above 1800 units was related to longer-term survival from SCLC. The present research is the first report of anti-Hu reactivity and SCLC in a population-based study. Given the suggestive evidence in this study, prospective analyses to examine whether anti-Hu reactivity might predict risk of developing SCLC, or whether anti-Hu reactivity could serve as an early marker for SCLC, may be warranted. |
| Author | Laird-Offringa, Ite A., PhD Kazarian, Meleeneh, BS Carpenter, Catherine L., PhD, MPH Tsou, Jeffrey A., PhD Patel, Ankur London, Stephanie J., MD Galler, Janice S., MS |
| AuthorAffiliation | 2 Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, 27709, USA 1 Departments of Biochemistry and Molecular Biology and of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA 3 Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA |
| AuthorAffiliation_xml | – name: 2 Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, 27709, USA – name: 1 Departments of Biochemistry and Molecular Biology and of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA – name: 3 Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA |
| Author_xml | – sequence: 1 fullname: Tsou, Jeffrey A., PhD – sequence: 2 fullname: Kazarian, Meleeneh, BS – sequence: 3 fullname: Patel, Ankur – sequence: 4 fullname: Galler, Janice S., MS – sequence: 5 fullname: Laird-Offringa, Ite A., PhD – sequence: 6 fullname: Carpenter, Catherine L., PhD, MPH – sequence: 7 fullname: London, Stephanie J., MD |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19070439$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_bbcan_2013_06_002 crossref_primary_10_1016_j_jneuroim_2009_08_014 crossref_primary_10_1007_s40242_018_7265_4 crossref_primary_10_1186_1476_4598_10_33 crossref_primary_10_1155_2016_2868190 crossref_primary_10_1080_2162402X_2017_1395125 crossref_primary_10_3892_mco_2017_1248 crossref_primary_10_1007_s13277_012_0379_2 crossref_primary_10_1158_1078_0432_CCR_10_1363 |
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| Keywords | PEM/SN Carcinoma Autoantibodies Case–control studies Small cell Paraneoplastic encephalomyelitis Survival HuD antigen |
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| Notes | Both authors contributed equally |
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| Snippet | Abstract Background : Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small... Background: Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung... Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC);... |
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| SubjectTerms | African Americans Aged Antibody Formation Autoantibodies Autoantibodies - blood Biomarkers, Tumor - blood Biomarkers, Tumor - immunology Carcinoma Case-Control Studies ELAV Proteins - blood ELAV Proteins - immunology European Continental Ancestry Group Female Follow-Up Studies Hematology, Oncology and Palliative Medicine HuD antigen Humans Lung Neoplasms - blood Lung Neoplasms - immunology Lung Neoplasms - mortality Male Middle Aged Paraneoplastic encephalomyelitis PEM/SN Risk Factors Small cell Small Cell Lung Carcinoma - blood Small Cell Lung Carcinoma - immunology Small Cell Lung Carcinoma - mortality Smoking - blood Smoking - immunology Survival Survival Analysis |
| Title | Low level anti-Hu reactivity: A risk marker for small cell lung cancer? |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0361090X08001281 https://dx.doi.org/10.1016/j.cdp.2008.06.006 https://www.ncbi.nlm.nih.gov/pubmed/19070439 https://pubmed.ncbi.nlm.nih.gov/PMC2952929 |
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