Ginger attenuates inflammation in a mouse model of dextran sulfate sodium-induced colitis

• Published in: Food science and biotechnology Vol. 27; no. 5; pp. 1493 - 1501
• Main Authors: Kim, Min Seo, Kim, Ji Yeon
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01-10-2018; Springer Nature B.V; 한국식품과학회
• Subjects: Body weight; Chemistry; Chemistry and Materials Science; Colitis; Colon; Cytokines; Dextran; Dextran sulfate; Distilled water; Food Science; Gene expression; Ginger; Inflammation; Inflammatory bowel disease; Interleukin 6; Intestine; Mice; Mucin; Nutrition; Peroxidase; Proteins; Rodents; Sodium; Sulfates; Tumor necrosis factor-TNF; Tumor necrosis factor-α; 식품과학; Inflammatory bowel disease; Inflammation; Colitis; Ginger; Dextran sulfate sodium
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-018-0438-6

This study assessed the anti-inflammatory effect of ginger extract on colitis by 5% dextran sulfate sodium (DSS) in BALB/c mice. The mice were administered either distilled water or three doses of ginger extracts for 21 days. We evaluated the change in clinical and histopathological signs and cytokine and gene expression levels. Contrary to the DSS group, the ginger groups increased body weight and inhibited shortening of the colon. DAI values and colon injury in the ginger groups were lower than that in the DSS group. Ginger groups obviously inhibited the myeloperoxidase activity and cytokine and mRNA concentrations of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, but not of intestinal barrier proteins zonula occludens (ZO)-1, occludin, E-cadherin, mucin-1, and mucin-2 in colon tissues. Our results suggest the protective effect of ginger against DSS-induced colitis and that ginger could be utilized to prevent and treat irritable bowel disease.