Interesterified fat or palm oil as substitutes for partially hydrogenated fat during the perinatal period produces changes in the brain fatty acids profile and increases leukocyte–endothelial interactions in the cerebral microcirculation from the male offspring in adult life

Abstract We investigated whether maternal intake of normolipidic diets with distinct fatty acid (FA) compositions alters the lipidic profile and influences the inflammatory status of the adult offsprings׳ brains. C57BL/6 female mice during pregnancy and lactation received diets containing either soy...

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Bibliographic Details
Published in:	Brain research Vol. 1616; pp. 123 - 133
Main Authors:	Misan, Vanessa, Estato, Vanessa, de Velasco, Patricia Coelho, Spreafico, Flavia Brasil, Magri, Tatiana, dos Santos, Raísa Magno de Araújo Ramos, Fragoso, Thaiza, Souza, Amanda S, Boldarine, Valter Tadeu, Bonomo, Isabela T, Sardinha, Fátima L.C, Oyama, Lila M, Tibiriçá, Eduardo, Tavares do Carmo, Maria das Graças
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 07-08-2015
Subjects:	Age Factors Analysis of Variance Animals Animals, Newborn Body Weight Brain - anatomy & histology Brain - growth & development Brain - metabolism Brain microcirculation Diet Dietary lipid Eating Endothelium - metabolism Fatty Acids - metabolism Female Humans Inflammation Interesterified fat Leukocytes - metabolism Male Metabolic programming Mice Mice, Inbred C57BL Microcirculation - physiology Neurology Palm Oil Plant Oils - administration & dosage Pregnancy Prenatal Exposure Delayed Effects Soybean Oil - administration & dosage Toll-Like Receptor 4 - metabolism Trans Fatty Acids - administration & dosage Brain microcirculation Interesterified fat Metabolic programming Dietary lipid Palm oil Inflammation
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