WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions

There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as dis...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; p. 46675
Main Authors:	Lee, Kendall H., Lujan, J. Luis, Trevathan, James K., Ross, Erika K., Bartoletta, John J., Park, Hyung Ook, Paek, Seungleal Brian, Nicolai, Evan N., Lee, Jannifer H., Min, Hoon-Ki, Kimble, Christopher J., Blaha, Charles D., Bennet, Kevin E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28-04-2017 Nature Publishing Group
Subjects:	119/118 631/378/1689 631/378/2632/1663 631/378/2632/2634 639/166/985 692/308/575 Animal models Animals Biosensing Techniques - methods Brain Brain - metabolism Brain - physiology Brain Diseases - diagnosis Brain Diseases - metabolism Brain Diseases - physiopathology Brain research Clinical trials Cognitive ability Deep brain stimulation Deep Brain Stimulation - methods Dopamine - metabolism Electric Stimulation Electrochemical Techniques - methods Feedback Female Humanities and Social Sciences Humans Macaca mulatta Male Mice multidisciplinary Neuromodulation Neurotransmitter Agents - metabolism Neurotransmitters Precision medicine Rats, Sprague-Dawley Science Swine Telemetry - methods Therapeutic applications
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