WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions

WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions

There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as dis...

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Published in:Scientific reports Vol. 7; no. 1; p. 46675
Main Authors: Lee, Kendall H., Lujan, J. Luis, Trevathan, James K., Ross, Erika K., Bartoletta, John J., Park, Hyung Ook, Paek, Seungleal Brian, Nicolai, Evan N., Lee, Jannifer H., Min, Hoon-Ki, Kimble, Christopher J., Blaha, Charles D., Bennet, Kevin E.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 28-04-2017
Nature Publishing Group
Subjects:
119/118
631/378/1689
631/378/2632/1663
631/378/2632/2634
639/166/985
692/308/575
Animal models
Animals
Biosensing Techniques - methods
Brain
Brain - metabolism
Brain - physiology
Brain Diseases - diagnosis
Brain Diseases - metabolism
Brain Diseases - physiopathology
Brain research
Clinical trials
Cognitive ability
Deep brain stimulation
Deep Brain Stimulation - methods
Dopamine - metabolism
Electric Stimulation
Electrochemical Techniques - methods
Feedback
Female
Humanities and Social Sciences
Humans
Macaca mulatta
Male
Mice
multidisciplinary
Neuromodulation
Neurotransmitter Agents - metabolism
Neurotransmitters
Precision medicine
Rats, Sprague-Dawley
Science
Swine
Telemetry - methods
Therapeutic applications
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Abstract There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni , which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedback for closed-loop control of neurochemical levels via its synchronized stimulation and neurochemical sensing capabilities. We demonstrate these and other key features of this platform in non-human primate, swine, and rodent models of deep brain stimulation (DBS). Ultimately, systems like the one described here will improve our understanding of the dynamics of brain physiology in the context of neurologic disease and therapeutic interventions, which may lead to the development of precision medicine and personalized therapies for optimal therapeutic efficacy.
AbstractList Abstract There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni , which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedback for closed-loop control of neurochemical levels via its synchronized stimulation and neurochemical sensing capabilities. We demonstrate these and other key features of this platform in non-human primate, swine, and rodent models of deep brain stimulation (DBS). Ultimately, systems like the one described here will improve our understanding of the dynamics of brain physiology in the context of neurologic disease and therapeutic interventions, which may lead to the development of precision medicine and personalized therapies for optimal therapeutic efficacy.
There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni , which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedback for closed-loop control of neurochemical levels via its synchronized stimulation and neurochemical sensing capabilities. We demonstrate these and other key features of this platform in non-human primate, swine, and rodent models of deep brain stimulation (DBS). Ultimately, systems like the one described here will improve our understanding of the dynamics of brain physiology in the context of neurologic disease and therapeutic interventions, which may lead to the development of precision medicine and personalized therapies for optimal therapeutic efficacy.
There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni, which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedback for closed-loop control of neurochemical levels via its synchronized stimulation and neurochemical sensing capabilities. We demonstrate these and other key features of this platform in non-human primate, swine, and rodent models of deep brain stimulation (DBS). Ultimately, systems like the one described here will improve our understanding of the dynamics of brain physiology in the context of neurologic disease and therapeutic interventions, which may lead to the development of precision medicine and personalized therapies for optimal therapeutic efficacy.
ArticleNumber 46675
Author Bennet, Kevin E.
Ross, Erika K.
Paek, Seungleal Brian
Lee, Kendall H.
Blaha, Charles D.
Park, Hyung Ook
Kimble, Christopher J.
Trevathan, James K.
Min, Hoon-Ki
Lee, Jannifer H.
Lujan, J. Luis
Nicolai, Evan N.
Bartoletta, John J.
Author_xml – sequence: 1
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  givenname: J. Luis
  surname: Lujan
  fullname: Lujan, J. Luis
  organization: Department of Neurologic Surgery, Mayo Clinic, Department of Physiology and Biomedical Engineering, Mayo Clinic
– sequence: 3
  givenname: James K.
  surname: Trevathan
  fullname: Trevathan, James K.
  organization: Mayo Graduate School, Mayo Clinic
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  givenname: Erika K.
  surname: Ross
  fullname: Ross, Erika K.
  organization: Department of Neurologic Surgery, Mayo Clinic
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  givenname: John J.
  surname: Bartoletta
  fullname: Bartoletta, John J.
  organization: Department of Neurologic Surgery, Mayo Clinic
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  organization: Department of Neurologic Surgery, Mayo Clinic
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  organization: Department of Neurologic Surgery, Mayo Clinic
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  surname: Lee
  fullname: Lee, Jannifer H.
  organization: Department of Neurologic Surgery, Mayo Clinic
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  surname: Min
  fullname: Min, Hoon-Ki
  organization: Department of Neurologic Surgery, Mayo Clinic, Department of Physiology and Biomedical Engineering, Mayo Clinic
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  givenname: Christopher J.
  surname: Kimble
  fullname: Kimble, Christopher J.
  organization: Division of Engineering, Mayo Clinic
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  givenname: Charles D.
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  organization: Department of Neurologic Surgery, Mayo Clinic
– sequence: 13
  givenname: Kevin E.
  surname: Bennet
  fullname: Bennet, Kevin E.
  organization: Department of Neurologic Surgery, Mayo Clinic, Division of Engineering, Mayo Clinic
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28452348$$D View this record in MEDLINE/PubMed
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SSID ssj0000529419
Score 2.4525337
Snippet There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed...
Abstract There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical...
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StartPage 46675
SubjectTerms 119/118
631/378/1689
631/378/2632/1663
631/378/2632/2634
639/166/985
692/308/575
Animal models
Animals
Biosensing Techniques - methods
Brain
Brain - metabolism
Brain - physiology
Brain Diseases - diagnosis
Brain Diseases - metabolism
Brain Diseases - physiopathology
Brain research
Clinical trials
Cognitive ability
Deep brain stimulation
Deep Brain Stimulation - methods
Dopamine - metabolism
Electric Stimulation
Electrochemical Techniques - methods
Feedback
Female
Humanities and Social Sciences
Humans
Macaca mulatta
Male
Mice
multidisciplinary
Neuromodulation
Neurotransmitter Agents - metabolism
Neurotransmitters
Precision medicine
Rats, Sprague-Dawley
Science
Swine
Telemetry - methods
Therapeutic applications
Title WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions
URI https://link.springer.com/article/10.1038/srep46675
https://www.ncbi.nlm.nih.gov/pubmed/28452348
https://www.proquest.com/docview/1903492392
https://search.proquest.com/docview/1893548062
https://pubmed.ncbi.nlm.nih.gov/PMC5408229
Volume 7
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