Quality Control of Multidrug Resistance Assays in Adult Acute Leukemia: Correlation Between Assays for P-Glycoprotein Expression and Activity

We have compared multiple assays for the P-glycoprotein (Pgp/MDR1) phenotype in fresh and thawed adult acute leukemia to validate and quantitate measures for the expression and function of Pgp. The results are related to the Pgp-expressing KB8 and KB8-5 cell lines. The most sensitive assay was the m...

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Bibliographic Details
Published in:	Blood Vol. 87; no. 11; pp. 4809 - 4816
Main Authors:	Broxterman, H.J., Sonneveld, P., Feller, N., Ossenkoppele, G.J., Währer, D.C.R., Eekman, C.A., Schoester, M., Lankelma, J., Pinedo, H.M., Löwenberg, B., Schuurhuis, G.J.
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 01-06-1996 The Americain Society of Hematology
Subjects:	Acute Disease Adult Antineoplastic agents ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biological and medical sciences Biological Transport - drug effects Chemotherapy Cryopreservation Daunorubicin - metabolism Daunorubicin - pharmacology Drug Resistance, Multiple Drug Resistance, Neoplasm Feasibility Studies Fluorescent Dyes Humans Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Leukemia, Myeloid - drug therapy Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Medical sciences Neoplasm Proteins - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Reproducibility of Results Rhodamine 123 Rhodamines Sensitivity and Specificity Verapamil - pharmacology Vincristine - metabolism Vincristine - pharmacology Human Antineoplastic agent Phenotype Reproducibility Acute Leukemia Multiple resistance Quality control P Glycoprotein Adult Malignant hemopathy Detection
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